|
一、基本情况： 赵丽娇，博士，教授，博士生导师。2006年7月毕业于北京工业大学生物医学工程专业，获得工学博士学位；博士毕业后留校任教至今，现为生命科学与生物工程学院环境与病毒肿瘤学北京市重点实验室教授，博士生导师。2008年赴美国麻省理工学院生物工程系从事访问学者研究；2012至2013年在美国明尼苏达大学Masonic癌症中心作为访问学者合作开展有关烟草特异亚硝胺导致食管癌的生物标志物研究。赵丽娇教授主要致力于环境中化学污染物的致癌机理和癌症生物标志物的研究，以及新型靶向性抗癌药物的研究。主持和参与的科研项目包括国家级、省部级、所在单位及企业项目共26项，其中主持多项国家自然科学基金面上项目、青年基金、北京市自然科学基金面上项目等课题，参与国家863计划等项目。入选2019年北京市“百千万人才”工程、2018年北京市“长城学者”计划、2009年北京市“科技新星”计划、2014北京工业大学“京华人才”计划；获得北京市委组织部优秀人才资助、北京市留学人员科技活动项目择优资助。以第一作者或通讯作者在SCI期刊上发表研究论文60余篇，以第一发明人获得发明专利授权7项、实用新型授权1项。担任核心期刊《化学试剂》副主编、核心期刊《北京工业大学学报》编委；兼任中国化学会、美国化学会、国际环境地球化学与健康学会、世界理论有机化学家协会会员。 主要学术贡献包括：（1）提出了环境中广泛存在的致癌物N-亚硝胺经代谢活化后导致DNA股间交联是其致癌作用的关键步骤，建立了N-亚硝基化合物分子结构与致癌活性关系，为准确预测N-亚硝胺环境暴露的致癌风险奠定了理论基础；（2）阐明了亚硝基脲抗癌和亚硝胺致癌作用机制的关键差异以及亚硝基脲类抗癌药物的耐药机制，为降低环境中N-亚硝胺的致癌风险、设计开发高效低毒的亚硝基脲类抗癌药物提供了科学依据；（3）发现了dG-dC横向交联可作为评价亚硝基脲抗癌活性的生物标志物，在此基础上设计合成了一类具有抗耐药活性的新型靶向性联合亚硝基脲前药，为开发具有自主知识产权的新型靶向性抗肿瘤药物提供了重要突破口。 主讲本科生《仪器分析》、《食品检测技术》和研究生《现代仪器分析实验》等课程。获得北京工业大学“优秀教学质量奖”、“优秀教育教学成果奖” 、“研途有您——我心目中的好导师”等荣誉称号。主持校教育教学研究课题、研究生课程建设项目等课题研究，入选北京工业大学青年导师国际化计划。培养的研究生中有多人获得国家奖学金、北京市优秀毕业生、北京工业大学优秀学位论文、校科技之星和十佳毕业生等荣誉称号。 二、工作经历： 2006年7月至2019年4月 北京工业大学生命科学与生物工程学院 教授 2008年4月至2008年10月 美国麻省理工学院生物工程系 访问学者 2012年6月至2013年6月 美国明尼苏达大学Masonic癌症中心 访问学者 2019年4月至今 北京工业大学环境与生命学部 教授 三、研究方向： 1. 新型靶向性抗肿瘤药物的设计、合成及活性研究 2. 环境致癌物对生物大分子的损伤作用及癌症生物标志物 3. 致癌物的代谢和致癌作用机理及其分子结构与致癌活性关系 4. 烷化剂类抗肿瘤药物的耐药机制 四、奖项荣誉： 1． 2020年北京市百千万人才支持计划 2．2018年北京市长城学者 3．2009年北京市科技新星 4．2008年北京市委组织部优秀人才计划 5．2015年北京工业大学京华人才 五、主要科研项目： 1. 国家自然科学基金面上项目（2018.01-2021.12，项目负责人）：
低氧激活联合亚硝基脲的作用机理及抗癌活性研究 2. 国家自然科学基金面上项目（2013.01-2016.12，项目负责人）：
环境中N-亚硝基化合物分子结构与致癌活性关系及其生物标志物研究 3. 国家自然科学基金青年基金项目（2010.01-2012.12，项目负责人）：
N-亚硝基化合物对DNA的损伤作用机制及相关构效关系 4. 北京市百千万人才支持计划（2020.01-2021.12，项目负责人）：
肿瘤低氧靶向性亚硝基脲纳米递送载体的构建及其活性评价 5. 北京市长城学者支持计划（2018.01-2021.04，项目负责人）：
低氧靶向性抗癌烷化剂的开发 6. 北京市自然科学基金面上项目（2016.01-2018.12，项目负责人）：
新型靶向性抗耐药亚硝基脲类烷化剂的设计、合成及抗肿瘤活性研究 7. 北京工业大学“京华人才”支持计划（2015.01-2017.12，项目负责人）：
新型靶向性亚硝基脲类抗癌药物的研究 8. 北京市留学人员科技活动择优资助项目（2015.01-2015.12，项目负责人）：
烟草特异亚硝胺导致肺癌的生物标志物研究 9. 北京市科技新星计划B类（2010.01-2012.12，项目负责人）：
N-亚硝基化合物对DNA的损伤作用及致癌机理研究 10. 北京市委组织部优秀人才资助项目（2008.01-2009.12，项目负责人）：
癌症相关标志物及应用研究 六、主要论文论著及专利： 1. Fangzheng Yin; Lijiao Zhao*; Lili Zhang; Yuhe Chen; Guohui Sun; Jintao Li; Na Zhang; Yuancong Xu; Paul KS Chan; Rugang Zhong. Chemopreventive role of apigenin against the synergistic carcinogenesis of human papillomavirus and 4-(methyl- nitrosamino)-1-(3-pyridyl)-1-butanone. Biomedicines, 2020, 8: 472. (SCI检索) 2. Zhuochen Zhuang; Jintao Li; Guohui Sun; Xin Cui; Na Zhang; Lijiao Zhao*; Paul KS Chan; Rugang Zhong. Synergistic effect between human papillomavirus 18 and 4‑(methylnitrosamino)-1-(3-pyridyl)-1-butanone on malignant transformation of immortalized SHEE cells. Chemical Research in Toxicology, 2020, 33: 470-481. (SCI检索) 3. Yao Ge; Xinxin Lai; Jintao Li; Ran Yu; Zhuochen Zhuang; Guohui Sun; in Cui; Na Zhang; Lijiao Zhao*; Pramod Upadhyaya; Rugang Zhong. NBGNU: a hypoxia- activated tripartite combi-nitrosourea prodrug overcoming AGT-mediated chemo- resistance. Future Medicinal Chemistry, 2019, 11: 269-284. (SCI检索) 4. Tengjiao Fan; Guohui Sun; Lijiao Zhao*; Xin Cui; Rugang Zhong. Metabolic activation and carcinogenesis of tobacco-specific nitrosamine N’-nitrosonornicotine (NNN): A density function theory and molecular docking study. International Journal of Environmental Research of Public Health, 2019, 16: 178. (SCI检索) 5. Weinan Xiao; Guohui Sun; Tengjiao Fan; Junjun Liu; Na Zhang; Lijiao Zhao*; Rugang Zhong. Reductive activity and mechanism of hypoxia targeted AGT inhibitors: An experimental and theoretical investigation. International Journal of Molecular Sciences, 2019, 20: 6308. (SCI检索) 6. Guohui Sun; Lijiao Zhao*; Rugang Zhong; Yongzhen Peng. The specific role of O6-methylguanine-DNA methyltransferase inhibitors in cancer chemotherapy. Future Medicinal Chemistry, 2018, 10: 1971-1996. (SCI检索) 7. Guohui Sun*; Tengjiao Fan; Xiaodong Sun; Yuxing Hao; Xin Cui; Lijiao Zhao*; Ting Ren; Yue Zhou; Rugang Zhong; Yongzhen Peng. In silico prediction of O6-methylguanine-DNA methyltransferase inhibitory potency of base analogs with QSAR and machine learning methods. Molecules, 2018, 23: 2892. (SCI检索) 8. Tengjiao Fan; Guohui Sun; Lijiao Zhao*; Xin Cui; Rugang Zhong. QSAR and classification study on prediction of acute oral toxicity of N-nitroso compounds. International Journal of Molecular Sciences, 2018, 19: 3015. (SCI检索) 9. Ting Ren; Xi Chen; Yao Ge; Lijiao Zhao*; Rugang Zhong. Determination of heavy metals in cigarettes using high-resolution continuum source graphite furnace atomic absorption spectrometry. Analytical Methods, 2017, 9: 4033-4043. (SCI检索) 10.Yameng Wang; Ting Ren; Xinxin Lai; Guohui Sun; Lijiao Zhao*; Na Zhang; Rugang Zhong. Synthesis and antitumor activity evaluation of a novel combinitrosourea prodrug: BGCNU. ACS Medicinal Chemistry Letters, 2017, 8: 174-178. (SCI检索) 11.Guohui Sun; Tengjiao Fan; Lijiao Zhao*; Yue Zhou; Rugang Zhong; The potential of combi-molecules with DNA-damaging function as anticancer agents. Future Medicinal Chemistry, 2017, 9: 403-435. (SCI检索) 12.Guohui Sun; Lijiao Zhao*; Tengjiao Fan; Ting Ren; Rugang Zhong. Measurement of O6-alkylguanine-DNA alkyltransferase activity in tumour cells using stable isotope dilution HPLC-ESI–MS/MS. Journal of Chromatography B, 2016, 1033: 138-146. (SCI检索) 13.Guohui Sun; Na Zhang; Lijiao Zhao*; Tengjiao Fan; Shufen Zhang; Rugang Zhong. Synthesis and antitumor activity evaluation of a novel combi-nitrosourea prodrug: Designed to release a DNA cross-linking agent and an inhibitor of O6-alkylguanine- DNA alkyltransferase. Bioorganic & Medicinal Chemistry, 2016, 24: 2097-2107. (SCI检索) 14.Guohui Sun; Lijiao Zhao*; Zhong Rugang. The induction and repair of DNA interstrand crosslinks and implications in cancer chemotherapy. Anti-Cancer Agents in Medicinal Chemistry, 2016, 16: 221-246. (SCI检索) 15.Guohui Sun; Tengjiao Fan; Na Zhang; Ting Ren; Lijiao Zhao*; Rugang Zhong. Identification of the structural features of guanine derivatives as MGMT inhibitors using 3D-QSAR modeling combined with molecular docking. Molecules, 2016, 21: 823. (SCI检索) 16.Lili Li, Sisi Li, Guohui Sun, Ruizeng Peng, Lijiao Zhao*, Rugang Zhong. Influence of the expression level of O-6-alkylguanine-DNA alkyltransferase on the formation of DNA interstrand crosslinks induced by chloroethylnitrosoureas in cells: A quantitation using high-performance liquid chromatography-mass spectrometry. Plos One, 2015, 10: UNSP e0121225. (SCI检索) 17.Guohui Sun; Lijiao Zhao*; Tengjiao Fan; Sisi Li; Rugang Zhong. Investigations on the effect of O6-benzylguanine on the formation of dG-dC interstrand cross-links induced by chloroethylnitrosoureas in human glioma cells using stable isotope dilution high-performance liquid chromatography electrospray ionization tandem mass spectrometry, Chemical Research in Toxicology, 2014, 27: 1253-1262. (SCI检索) 18.Lijiao Zhao*; Lili Li; Jie Xu; Rugang Zhong. Comparative investigation of the DNA inter-strand crosslinks induced by ACNU, BCNU, CCNU and FTMS using high-performance liquid chromatography-electrospray ionization tandem mass spectrometry. International Journal of Mass Spectrometry, 2014, 368: 30-36. (SCI检索) 19.Lili Li; Lijiao Zhao*; Rugang Zhong. Quantification of DNA interstrand crosslinks induced by ACNU in NIH/3T3 and L1210 cells using high-performance liquid chromatography/electrospray ionization tandemmass spectrometry. Rapid Communicatioin in Mass Spectrometry, 2014, 28: 439-447. (SCI检索) 20.Zhao, Lijiao; Balbo, Silvia; Wang, Mingyao; Pramod Upadhyaya; Samir S. Khariwala; Peter W. Villalta; Stephen S. Hecht*. Quantitation of pyridyloxobutyl-DNA adducts in tissues of rats treated chronically with (R)- or (S)-N'-nitrosonornicotine (NNN) in a carcinogenicity study. Chemical Research in Toxicology, 2013, 26: 1526-1535. (SCI检索) 21.Tingting Liu, Lijiao Zhao*, Rugang Zhong. DFT study of phosphotriesters hydrolysis in aqueous solution: a model study for DNA single strand scission induced by N-nitrosoureas. Journal of Molecular Modeling, 2013, 19: 647-659. (SCI检索) 22.Lijiao Zhao*, Xinyan Ma, Rugang Zhong. A DFT investigation on the formation mechanisms of DNA interstrand crosslinks induced by chloroethylnitrosoureas. International Journal of Quantum Chemistry, 2013, 113: 1299-1306. (SCI检索) 23.Ting Ren, Lijiao Zhao*, Bosi Sun, Rugang Zhong. Determination of lead, cadmium, copper, and nickel in the Tonghui River of Beijing, China, by cloud point extraction-high resolution continuum source graphite furnace atomic absorption spectrometry. Journal of Environmental Quality, 2013, 42: 1752-1762. (SCI检索) 24.Lijiao Zhao*, Xinyan Ma, Rugang Zhong. Comparative theoretical investigation of the mechanism of DNA interstrand crosslinks induced by two N-nitroso compounds: nitrosoureas and nitrosamines. Journal of Physical Organic Chemistry, 2012, 25: 1153-1167. (SCI检索) 25.Jun Cao, Lijiao Zhao*, Shubin Jin, Rugang Zhong. Relationship between the molecular structure and the anticancer activity of N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosoureas: A theoretical investigation. International Journal of Quantum Chemistry, 2012, 112: 747-758. (SCI检索) 26.Lijiao Zhao*, Ting Ren, Rugang Zhong. Determination of lead in human hair by high resolution continuum source graphite furnace atomic absorption spectrometry with microwave digestion and solid sampling. Analytical Letters, 2012, 45: 2467-2481. (SCI检索) 27.Baoqing Bai, Lijiao Zhao*, Rugang Zhong. Quantification of meCCNU-induced dG-dC crosslinks in oligonucleotide duplexes by liquid chromatography/ electrospray ionization tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 2011, 25: 2027-2034. (SCI检索) 28.Lijiao Zhao*, Tingting Liu, Rugang Zhong. A comparison of the stereoisomeric penta-coordinated phosphorus intermediates formed from 19 dimethoxyl N-phosphoryl amino acids by DFT calculations. Journal of Theoretical and Computational Chemistry, 2011, 10: 217-229. (SCI检索) 29.赵丽娇; 余然; 葛瑶; 任婷; 宋秀庆; 钟儒刚. 一种偶氮芳香氮芥氯乙基亚硝基脲偶联的化合物及制备方法和应用(专利号ZL201711049998.4). 专利授权, 授权日2019-12-25. 30.赵丽娇; 余然; 张黎黎; 宋秀庆; 钟儒刚. 靶向肿瘤低氧的偶氮芳香氮氧化物-氯乙基亚硝基脲偶联分子及其制备方法和应用(专利号ZL201810200016.5). 专利授权, 授权日2019-10-10. 31.赵丽娇; 刘俊俊; 赖新鑫; 宋秀庆; 任婷; 钟儒刚. 低氧激活O6-苄基-2-硝基嘌呤衍生物及制法和应用(专利号ZL201710377712.9). 专利授权, 授权日2019-7-18. 32.赵丽娇; 赖新鑫; 孙国辉; 任婷; 宋秀庆; 钟儒刚. 一种低氧激活AGT蛋白抑制剂及其制备方法与应用(专利号ZL201610448022.3). 专利授权, 授权日2017-9-12. 33.赵丽娇; 彭瑞增; 任婷; 张淑芬; 钟儒刚. 低氧激活联合氯乙基亚硝基脲类化合物及制备方法和应用(专利号ZL201511017787.3). 专利授权, 授权日2017-9-5. 34.赵丽娇; 李莉莉; 王雅朦; 钟儒刚. 一种新型的具有抗癌活性的氯乙基亚硝基脲及其合成方法(专利号ZL201410231185.7). 专利授权, 授权日2015-12-4. 35.赵丽娇; 孙国辉; 钟儒刚. 一种新型的β-氯乙基亚硝基脲类化合物及其合成方法和用途(专利号ZL201410231997.1). 专利授权, 授权日2015-12-4. 七、招生方向： 1.博士研究生招生方向： 083100生物医学工程：08分子毒理学与癌症防治 2.硕士研究生招生方向： 0710生物学：03药物化学与化学生物学、04环境生物学与食品安全 0703化学 0854生物医学工程（专业学位）：04药物新技术与食品安全 八、联系方式： 北京市朝阳区平乐园100号， 北京工业大学生命科学与生物工程学院（北工大理科楼B213室） 邮政编码：100124 E-mail: zhaolijiao@bjut.edu.cn 手机：13910167017（微信同号）
|