基本信息

徐坤，1986年生，中国科学技术大学与Rutgers University联合培养博士，2014年获有机化学博士学位，导师汪志勇教授，张绪穆教授。2018年4月入选“北京工业大学高层次人才”优秀人才计划，现任北京工业大学教授，博士生导师。主持面上项目等国家自然科学基金三项，以通讯作者在Angewandte Chemie,CCS Chemistry,Science China Chemistry,Chemical Science，Science Bulletin等期刊上发表研究论文40余篇，其中封面文章4篇，ESI热点文章1篇，ESI高被引论文7篇。入选2022、2023年度“全球前2%顶尖科学家榜单”。兼任催化联盟青年工作委员会委员，Chin. J. Org. Chem.青年编委。

研究方向

光电绿色催化与合成；药物分子骨架的绿色合成

招生方向

博士：生物医学工程06药物合成与新技术应用

硕士：化学（学硕），材料与化工（专硕）

主持的国家科研项目

基于LMCT机制的难氧化高键能化学键的电化学氧化活化研究（国家自然科学基金2022-2025）

钴催化的羧酸化合物的脱羧胺化反应研究（国家自然科学基金2017-2019）

电化学诱导的自由基加成反应在含氮稠杂环合成中的应用（国家自然科学基金2016-2018）

近期代表性研究论文

1.Electrochemical Synthesis of trans-2,3-Disubstituted Aziridines via Oxidative Dehydrogenative Intramolecular C(sp3)–H Amination. Org. Lett.,2019,21, 9430–9433.

2. Nickel-catalyzed electrochemical reductive decarboxylative coupling of N-hydroxyphthalimide esters with quinoxalinones.Chem. Commun.,2019,55, 14685–14688.

3. Organic Photoredox-Catalyzed Synthesis of δ-Fluoromethylated Alcohols and Amines via 1,5-Hydrogen-Transfer Radical Relay.Org. Lett.,2019,21, 5116–5120.

4.Electrochemical fluoromethylation triggered lactonizations of alkenes under semi-aqueous conditions.Chem. Sci.,2019,10, 3181–3185.

5. Nickel-catalyzed electrochemical Minisci acylation of aromatic N-heterocycles with α-keto acids via ligand-to-metal electron transfer pathway.J. Catal.,2020,381, 38–43.

6. Electroreductive 4-Pyridylation of Electron-deficient Alkenes with Assistance of Ni(acac)₂.Org. Lett.,2020,22, 3570–3575.

7. Electrochemical synthesis of selenocyanated imidazo[1,5-a]quinolines under metal catalyst- and chemical oxidant-free conditions.Chin. Chem. Lett.,2020,31, 1576-1579.

8. Regioselective C–H Phosphorothiolation of (Hetero)arenes Enabled by the Synergy of Electrooxidation and Ultrasonic Irradiation.Org. Lett.,2021,23, 4214–4218.

9. Access to Deuterated Unnatural α-Amino Acids and Peptides by Photochemical Acyl Radical Addition.Org. Lett.,2021,23, 5299–5304.

10.Electrochemical Arylation of Aldehydes, Ketones, and Alcohols: from Cathodic Reduction to Convergent Paired Electrolysis. Angew. Chem. Int. Ed.,2021,60, 7275-7282.

11. Tandem Strecker/C(sp3)–H amination reactions for the construction of cyanide-functionalized imidazo[1,5-a]pyridines with NH₄SCN as a cyanating agent.Org. Chem. Front.,2021,8, 6384-6389.

12. Regioselective intramolecular sp2 C–H amination: direct vs. mediated electrooxidation.Org. Chem. Front.,2021,8, 1581-1586.

13. Electrochemical Organoselenium-Catalyzed Intermolecular Hydroazolylation of Alkenes with Low Catalyst Loadings.Org. Lett.2022,24, 5345-5350.

14. Electrophotocatalytic C−H Functionalization of N-Heteroarenes with Unactivated Alkanes under External Oxidant-Free Conditions.ChemSusChem2022,15, e202102360.

15. Electrophotocatalytic Si–H Activation Governed by Polarity-Matching Effects.CCS Chem.2022,4, 1796-1805.

16. The synergism of sequential paired electrosynthesis with halogen bonding activation for the cyclization of organochlorides with olefins.Sci. Chin. Chem.2023,66,540-547.

17. Electrophotoredox/cerium-catalyzed unactivated alkanes activation for the sustainable synthesis of alkylated benzimidazo-fused isoquinolinones.J. Catal.,2023,417, 473–480.

18. Direct alkylation of quinoxalinones with electron-deficient alkenes enabled by a sequential paired electrolysis.Chem. Commun.,2023,59, 12763-12766.

19. Multicomponent Synthesis of 5-Cyano-pyrazolo[1,5-a]pyrimidines Enabled by Aerobic Manganese Catalysis.Adv. Synth. Catal.,2023,365, 871-876.

20. Electrochemical Atom Transfer Radical Addition of Polychloroalkanes to Olefins Promoted by 4,4-Di-tert-butyl Bipyridine.Chin. J. Chem.,2023,41, 1583-1588.

21. Paired Electrolysis Enabled Trifluoromethylheteroaromatization of Alkenes and Alkyne with Trifluoromethyl Thianthrenium Triflate (TT-CF3+OTf–) as a Bifunctional Reagent.Org. Lett.2023,DOI: 10.1021/acs.orglett.3c04124.

22. Electrochemical Umpolung Enabled Radical–Radical Cross-Coupling Between Electron-Deficient Methylarenes and Aldehydes.CCS Chem.2023,5, 1973-1981.

邀请综述

1. C. Ma, P. Fang, Z.-R. Liu, S.-S. Xu,K. Xu*, X. Cheng*, A. W. Lei*, H.-C. Xu*, C. C. Zeng*, T.-S. Mei*, Recent advances in organic electrosynthesis employing transition metal complexes as electrocatalysts.Sci. Bull.2021,66, 2412-2429.

2. J. Li, S. Zhang*,K. Xu*, Recent advances towards electrochemical transformations of α-keto acids.Chin. Chem. Lett.2021,32, 2729-2735.

3. F. Lian,K. Xu*, C. C. Zeng*, Indirect Electrosynthesis with Halogen Ions as Mediators.Chem. Rec.2021,21, 2290-2305.

4. X. Chen*, A. Lei*, T.-S. Mei*, H.-C. Xu*,K. Xu*, C. Zeng*, Recent Applications of Homogeneous Catalysis in Electrochemical Organic Synthesis.CCS Chem.2022,4, 1120-1152.

5. H. Zhang, S. Liang, D. Wei,K. Xu*, C. Zeng*, Electrocatalytic Generation of Acyl Radicals and Their Applications.Eur. J. Org. Chem.2022, e202200794.

6. Z. Tan, H. Zhang,K. Xu*, C. Zeng*, Electrochemical radical-polar crossover: a radical approach to polar chemistry.Sci. Chin. Chem.2023, DOI: 10.1007/s11426-023-1735-x.