课题或论文情况
4.1项目
国家十三五重大科技：专项艾滋病和病毒性肝炎等重大传染病防治研究项目
北京市教委科技计划重点项目：固相模板引导的[2+2]光环合反应在四星烷合成中的应用研究
国家自然科学基金：离子液体应用于多面体烷的[2+2]光环合反应的研究
北京市自然科学基金重点项目：新型亚硝基脲的合成及抗肿瘤活性的研究
国家十二五科技重大专项：艾滋病和病毒性肝炎等重大传染病防治研究
北京市科研基地—科技创新平台—抗肿瘤创新药物的研制
企事业委托项目：新型药物色瑞替尼（Zykadia）的质量标准的建立
企事业委托项目：普拉克索合成工艺优化和质量标准的建立
企事业委托项目：新型EGFR抑制剂Osimertinib及其甲磺酸盐的合成、晶型及光稳定性研究
4.2代表性成果
1.Shengquan Hu, Libin Yuan, Hong Yan, Zhigang Li, Design, synthesis and biological evaluation of Lenalidomide derivatives as tumor angiogenesis inhibitor, Bioorganic & Medicinal Chemistry Letters, 27 (2017) 4075–4081.
2.Hong-bo Tan, Xiu-qing Song, Hong Yan, Hong-xing Xin Synthesis, NMR analysis and X-ray crystal structure of 3-(2-naphthoyl)-6,12-diphenyl-3,9-diazatetraasterane, Journal of Molecular Structure, Volume 1129, 2017, 23-31.
3.Xiuqing Song; Hongbo Tan; Hong Yan; Yu ChangStructural analysis of N,N-diacyl-1,4-dihydropyrazine by variable-temperature NMR and DFT calculation，Journal of Molecular Structure, 2017, 1134, 606-610
4.Qidi Zhong; Qiangwen Fan; Hong Yan, Synthesis of 2,3-dihydropyrroles by photo rearrangement of Hantzsch 1,4-dihydropyridines with high diastereoselectivity, Tetrahedron Letters, 2017, 58, 1292–1295
5.Shunyi Wang, Wuji Sun, Qin Hu, Hong Yan * and Yi Zeng, Synthesis and evaluation of pyridinium polyoxometalates as anti-HIV-1 agents, Bioorganic & Medicinal Chemistry Letters, 2017, 27,2357–2359
6.闫红，樊强文，宋秀庆，谭洪波，李泽琳，曾毅, 2,5,8,11-四氮杂四星烷类化合物及其制备方法和应用,授权，ZL201410758272.8，20170408
7.闫红，王业明，胡盛全，6-腙基-8-氮杂嘌呤类化合物及其制备方法和应用，国家发明专利，201710233181.6
8.闫红，赵志昌，胡盛全等.一种AZD9291的制备方法.申请号：201710332881.0.
9.Hongxing Xin, Xiaohe Zhu, Hong Yan,* and Xiuqing Song，Revelation from the Reaction of 1,4-Diazabutadiene with Perchloric Acid: An Approach to the Synthesis of Imidazolium Perchlorates，J. Heterocyclic Chem., 2016, 53, 1363–1366.
10.Zong-Shan Ma, Qiang-wen Fan, Hong Yan* and Da-Hai Yu, A FGFR-2 Inhibitor, Ki23057, Evaluated as a Novel VEGFR-2 Kinase Inhibitor, Journal of Pharmacy and Pharmaceutical Sciences, 2016, 5, 2322-0112.
11.Hong-bo Tan, Qi-di Zhong & Hong Yan*: Studies on the Photochemical Oxidation of N,N-Diacyl-1,4-dihydropyrazine Derivatives, Synthetic Communications, 2016, 46, 1-10.
12.闫红，孙武积，胡秦，艾萍，一种Keggin结构杂多酸含磷有机盐类化合物、制备方法和应用，中国发明专利，申请号，201610327268.5，公开号，CN 105968134 A
13.李泽林，曾毅，闫红，艾萍，胡秦，含氮的钨钛杂多酸盐类化合物、其制备方法和医药用途，中国发明专利，申请号，201610944674.6
14.李泽林，曾毅，闫红，艾萍，胡秦，多酸化合物、其制备方法和医药用途，中国发明专利，申请号，201610172956.9
15.Hongbo Tan, Xiuqing Song, Hong Yan. Photochemical Oxidation of N,N-bis-(tert-butoxycarbonyl)-1,4-Dihydropyrazine Derivatives. Heterocyclic Communications. 2015, 21, 83-88.
16.Yeming Wang, Hong Yan*, Chao Ma b , Dan Lu, Synthesis and anticancer activities of novel 8-azapurine carbocyclic nucleoside hydrazones, Bioorganic & Medicinal Chemistry Letters, 2015, 25, 4461–4463
17.Libin Yuan, Qiangwen Fan, Hong Yan & Xiu-Qing Song, Synthesis and Molecular Structure Characterization of Novel 1,6-Diazahexatrienes, Synthetic Communications 2015, 11(45), 1301-1310.
18.Wuji Sun, Yangye Jiang, Hong Yan*, and Xiuqing Song, Synthesis and Photoreaction of 2-Amino-3-cyano-4-aryl-4H-pyrans, Aust. J. Chem. 2015, 68, 273–281.
19.闫红，钟启迪，孙武积，宋秀庆，2,3-二氢吡咯类化合物、制备方法及其应用，发明专利，申请号201510967662.0，公开号CN 105399654 A
20.闫红；樊强文；高磊；任绘君,一种硝基多面体烷化合物2,5,8,11-四硝基四氮杂四星烷及其制备方法, 2015/8/19,北京, CN201510134722.0.
21.闫红；樊强文；宋秀庆；谭洪波；李泽琳；曾毅, 2,5,8,11-四氮杂四星烷类化合物及其制备方法和应用, 2015/4/22,北京, CN201410758272.8.
22.闫红；王业明；钟启迪；任绘君；高磊,一种替格瑞洛的制备方法, 2015/7/22,北京, CN201510125844.3.
23.闫红；王业明；孙武积；任绘君；樊强文,一种卡格列净半水合物及其单晶的制备方法, 2015/7/1,北京, CN201510140816.9.
24.Ye, Jingrong; Lu, Hongyan; Su, Xueli; Xin, Ruolei; Bai, Lishi; Xu, Ke; Yu, Shuangqing; Feng, Xia; Yan, Hong*; He, Xiong; Zeng, Yi,Phylogenetic and Temporal Dynamics of Human Immunodeficiency Virus Type 1B in China: Four Types of B Strains Circulate in China, AIDS Research and Human Retroviruses, 30(9),920-926, 2014/9.
25.Xiaowei Duan, Hongxing Xin, Hong Yan. Design, Synthesis, and Biological Evaluation of 1,4-Diaryl-1,4-dihydropyrazines as Novel 11 β -HSD1 Inhibitors. Biological & Pharmaceutical Bulletin, 2014, 37(5): 840-846.
26.Liu, Peng; Xin, Hong-Xing; Song, Xiu-Qing; Yan, Hong, Structure Characterization of Novel 1,6-Diazahexiatrienes,Diethyl(E)-2,3-bis[(E)-(2-methyl-2-phenylhydrazin-1-ylidene)methyl]but-2-enedioate, Acta CrystallographicaSection E: Structure Reports Online,2014, 70, s o723.
27.Hongbo, Tan; Hongxing, Xin; Hong, Yan. SYNTHESIS AND PHOTOCHEMICAL PROPERTIES OF 2,4,6,-TRIARYL-4H-1,4-OXAZINES. HETEROCYCLES Vol. 89, No. 2 (2014), 359-373.
28.Xin, H.; Sun, W.; Yan, H.; Song, X., Photochemical ring contraction of 1-aryl-1,4-dihydropyrazine to 1-aryl-1H-imidazoleJournal of Photochemistry and Photobiology A: Chemistry, Volume(s) 267, 29-Jun-2013, Pages 49-54
29.H.L. ZHANG, X.H. ZHU,H. YAN* and X.Q. SONG,Highly Efficient, Selective,Ultrasound-Assisted Monohydrolysis of Polyhedral Diesters in a Co-solvent, Asian Journal of Chemistry; 25,7351-7354,2013.
30.Yanlan Liu, Hongbo Tan, Hong Yan* and Xiuqing Song, Design, synthesis and biological evaluation of 3,9-diazateraasteranes as novel matrilysin inhibitors Chem Biol Drug Des, 82, 567–578, 2013.
31.Xiao-He Zhu, Xin Zhang, Hong-Xing Xin, Hong Yan*, A Transformation of N-alkylated Anilines to N-Aryloxamates, Helvetica Chimica Acta,96, 1542-1547, 2013.
32.Hongxing Xin, Wuji Sun, Hong Yan∗, Xiuqing Song Photochemical ring contraction of 1-aryl-1,4-dihydropyrazine to 1-aryl-1H-imidazole, Journal of Photochemistry and Photobiology A: Chemistry 267, 49-54, 2013.
33.Weipeng Li, Jian Wang, Hongxing Xin, Hong Yan*,Synthesis of 4H-1,4-oxazines as transthyretin amyloid fibril inhibitors,Organic & Biomolecular Chemistry, 11, 4546-4550, 2013.
34.Hongxing Xin, Xiaohe Zhu, Hong Yan*, Xiuqing Song, A Novel Photodimerization of 4-Aryl-4H-pyrans for Cage Compounds，Tetrahedron Letters, 54, 3325–33282013.
35.Jian Wang, Peng Li, Chengliang Ni, Hong Yan, Rugang Zhong,A one-pot synthesis of camphorquinone from camphor,Synthetic Communications, 43: 1543–1548, 2013.
36.Xiaohe Zhu, Weipeng Li, Hong Yan*, Rugang Zhong. Triplet Phenacylimidazoliums Catalyzed Photocycloaddition of 1,4-Dihydropyridines: an Experimental and Theoretical Study. Journal of Photochemistry & Photobiology A: Chemistry, 241: 13-20, 2012.
37.张宏雷,朱晓鹤,闫红*,宋秀庆.多面体烷氯乙基脲的合成新方法研究.有机化学, 32: 344-348, 2012.
38.闫红，倪成良，朱晓鹤，宋秀庆，钟儒刚，高立方烷二酰胺类化合物及其应用，发明专利，ZL200810223965.1, 2012.
39.Jiaojiao Duan, Xiaohui Song, Hong Yan*, and Xiuqing Song，Optimization of the Selective Monohydrolysis of Diethyl 4-Aryl-4H-pyran-3,5-dicarboxylates, Molecules, 16, 3845-3854, 2011.
40.Xiu-Qing Song, Cheng-Liang Ni, Hong Yan*, Hui-Qin Wang, Ru-Gang Zhong, Tetraethyl 2,4,8,10-tetramethyl-6,12-bis(4-fluorophenyl)-3,9-dioxapentacyclo[6.4.0.02,7.04,11.05,10]dodecane-1,5,7,11-tetracarboxylate: Synthesis, NMR analysis and X-ray crystal structure,Journal of Molecular Structure,1006,489–493,2011.
41.Yu Qin, Hong F. Deng, Hong Yan*, Ru G. Zhong, Accurate nonlinear QSAR model for the antitumor activities of CENUs using neural networks, Journal of Molecular Graphics and Modelling，29 (2011) 826–833.
42.朱晓鹤，倪成良，宋秀庆，闫红*，钟儒刚，3,9-二氮杂四星烷类化合物的合成研究，有机化学,30, 276-281, 2010.
43.C.L. Ni, X.H. Song, H. Yan*, X.Q. Song, R.G. Zhong, Improved synthesis of diethyl 2,6-dimethyl-4-aryl-4H-pyran-3,5-dicarboxylate under ultrasound irradiation, Ultrasonics Sonochemistry,17, 367-369, 2010.
44.Xiaohe Zhu, Yu Qin, Hong Yan*, Xiuqing Song, and Rugang Zhong,Synthesis, Biological Evaluation, and Molecular Modeling Studies of N-aryl-2-arylthioacetamides as Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors, Chem Biol Drug Des,1-10,2010.
45.闫红，倪成，王惠琴，温瑞兴,钟儒刚,李泽琳,曾毅，3,9-二氧杂四星烷类化合物及其制备方法和应用，ZL200710098802.0, 2010.
46.Zhong Qidi; Xue Yunzhou; Hong Yan*,Song Xiuqing; Zhong Rugang,Preparation of 4,7-Diphenyl-1,10-Phenanthroline-2,9-Dicarboxylic Acid Catalyzed by Iron(III)porphyrins with (Diacetoxyiodo)benzene, Bioorganic & Medicinal Chemistry Letters, 20, 5532–5535, 2010.
47.X.H. Zhu, C.L. Ni, H. Yan*, R.G. Zhong,Synthesis and X-ray Crystallographic Analysis of 1,4-dihydropyridine Photodimerization,J. Photopolym. Sci. Technol,22, 379-384,2009.
