赵洪武

职称职务:副研究员 硕士生导师

E-mail:hwzhao@bjut.edu.cn

通讯地址:北京市朝阳区平乐园100号, 北京工业大学环境与生命学部,化学与生系,生命楼B624研究室

基本信息

    教育背景

1997年--2000年,北京大学,化学与分子工程学院,博士

1992年--1995年,东北师范大学,化学系,硕士

1988年--1992年,东北师范大学,化学系,本科

工作经历

2007年--现在,北京工业大学,副研究员

2006年--2007年,开拓者制药公司(美国Eli Lilly),研发总监

2004年--2006年,美国普渡大学,药学院,博士后

2001年--2004年,美国弗吉尼亚理工大学,化学系,博士后

2000年--2001年,香港大学,化学系,博士后

1995年--1997年,大连理工大学,石油化工学院,讲师

研究方向

1.靶向性抗肿瘤药物的设计与合成

2.手性螺(稠)杂环类药性分子骨架的设计与合成

3.不对称有机催化和金属催化有机合成方法学的研究

4.超分子化学:手性识别的研究

课程教学

有机化学(本科生/主讲)、生物材料(本科生/主讲)、药物合成(科生/主讲/双语)、药物化学(研究生/主讲/双语/)、生物医学工程概论(本科生/主讲)、药物合成技术(研究生/主讲)

奖项荣誉

1.北京工业大学优秀硕士学位论文指导教师(13次)

2.北京工业大学绩效考核优秀奖(6次)

3.北京工业大学“双带头人”教师党支部书记示范工作室(2019年)

4.生命科学与生物工程学院(原)优秀共产党员(2017年)

5.北京市人才强教深化计划中青年骨干人才(2010年)

科研项目

作为项目负责人,主持国家科技重大专项1项、北京市自然科学基金(面上)4项、北京市教委项目2项、北京市人才强教深化计划中青年骨干人才项目1项、企业委托项目2项、校级项目2项。作为研究骨干,参与了国家重点基础研究发展计划2项、国家科技重大专项2项、北京市教委项目1项。

1.新型P53-MDM2小分子抑制剂的设计、合成及抗肿瘤活性评价,北京市自然科学基金,2022/01-2024/12

2.吲哚类和喹啉酮类化合物合成,企事业委托项目,主持,2020/11-2022/12

3.靶向FBPase的抗糖尿病新药研究病,国家重大专项,主持,2018/01-2020/12

4.新型手性螺环巴比妥的设计、合成和抗肿瘤活性评价药研究,北京市自然科学基金,主持,2017/01-2019/12

5.新型双功能小分子催化剂的设计、合成和不对称催化反应的研究,北京市自然科学基金,主持,2012/01-2014/12

6.新型桥连联苯化合物的设计、合成与抗肿瘤活性研究,北京市自然科学基金,主持,2010/01-2012/12

7.新型(-)-Rhazinilam桥连联芳基化合物的设计、立体选择性合成和构效关系研究,北京市人才强教计划,主持,2010/01-2013/12

8.新型秋水仙碱B环类似物的设计、合成和构效关系研究,北京市教委项目,主持,2009/01-2011/12

9.芳基二氢吡啶酮化合物的合成,企事业委托项目,主持,2010/01-2011/12

论文论著

J. Am. Che. Soc.,Org. Lett.,Chem. Commun.Adv. Synth. & Catal.,J. Org. Chem.等SCI收录的国际著名学术刊物上发表科研论文50余篇;申请国家发明专利10余项。

科技论文(SCI收录)

1.Lu-Yu Cai, Heng Zhang, Kuo Wang,Hong-Wu Zhao,*Pd-Catalyzed Decarboxylative Coupling Between Allyl Carbonates and Vinyl Benzoxazinanones,Adv. Synth.&Catal.,2022, 364, 1738-1749

2.Heng Zhang, Lu-Yu Cai, Kuo Wang,Hong-Wu Zhao,*Pd-Catalyzed three-component decarboxylative coupling reactions between alkylidene pyrazolones, allyl carbonates and active methylene compounds,Org. Biomol. Chem.,2022, DOI 10.1039/d2ob00791f

3.Xiao-Zu Fan, Hui-Hui Wu, Zhe Tang, Heng Zhang, Lu-Yu Cai, Xiao-Fan Bi, Hong-Wu Zhao,*Formal [3+2] Cycloaddition Between in situ Formed 1,4-Benzodiazepin-2-One-Based Azomethine Ylides with Azodicarboxylic Acid Derivatives: Diastereoselective Synthesis of Spiro-1,4-Benzodiazepin-2-Ones,Adv. Synth.& Catal.,2021, 5, 1379-1389

4.Hui-Hui Wu, Xiao-Zu Fan, Zhe Tang, Heng Zhang, Lu-Yu Cai, Xiao-Fan Bi,Hong-Wu Zhao,*Palladium/Ligand Complex Catalyzed Formal [5 + 6] Cycloaddition of Vinylethylene Carbonates with Isatoic Anhydrides for Synthesis of Medium-Sized N,O-Containing Heterocycles,Org. Lett.,2021, 7, 2802-2806

5.Jia-Ming Guo, Xiao-Zu Fan, Hui-Hui Wu, Zhe Tang, Xiao-Fan Bi, Heng Zhang, Lu-Yu Cai,Hong-Wu Zhao,*and Qi-Di Zhong. Asymmetric Synthesis of Spiropyrazolones via Chiral Pd(0)/Ligand Complex-Catalyzed Formal [4+2] Cycloaddition of Vinyl Benzoxazinanones with Alkylidene Pyrazolones,J. Org. Chem.2021,2, 1712-1720

6.H. W. Zhao,*L. R. Wang, W. Q. Ding, et al. Formal [5+3] Cycloaddition between Isatin-Basedα-(Trifluoromethyl)imine Ylides and Vinyloxiranes: Diastereoselective Access to Medium-Heterocycle-Fused Spirooxindoles,Synlett,2021, 32, 57-62

7.Heng Zhang, Lu-Yu Cai, Zhe Tang, Xiao-Zu Fan, Hui-Hui Wu, Xiao-Fan Bi,Hong-Wu Zhao,1,3-Dipolar [3+3] Cycloaddition of 1,4-Benzodiazepinone-Based Nitrones with alpha-Halohydroxamates for Diastereoselective Synthesis of Novel d-Edge Heterocycle-Fused 1,4-Benzodiazepinones,Synlett,2021, 19, 1974-1980

8.Xiao-Fan Bi, mHai-Liang Pang, Zhe Tang, Heng Zhang, Lu-Yu Cai, Hui-Hui Wu, Xiao-Zu Fan,Hong-Wu Zhao,*Stereoselective Synthesis of Polyfunctionalized Nitrones through Conjugate Addition of alpha-Halo Hydrazones to Nitroso Compounds, Synlett,2021, 14, 1457-1460

9.Zhe Tang, Hui-Hui Wu, Xiao-Zu Fan, Heng Zhang, Lu-Yu Cai, Xiao-Fan Bi,Hong-Wu Zhao,*Diastereoselective Synthesis of Spiropyrazolones via 1,3-Dipolar [3+2] Cycloadditions between Pyrazolone-Based Olefins and N,N '-Cyclic Azomethine Imines, Synlett,2021, 12, 1201-1206

10.H. W. Zhao,*W. Q. Ding, L. R. Wang, et al Formal [5+2] Cycloaddition of Vinyloxiranes with Oxazol-5-(4H)-ones: A Facile Approach for Construction of Seven-Membered Lactones,Eur. J. Org. Chem.,2020, 2020(34), 5557-5562

11.H. W. Zhao,*J. M. Guo, L. R. Wang, et al.Diastereoselective formal [3+3] cycloaddition of isatin-based alpha-(trifluoromethyl)imines with N,N '-dialkyloxyureas,Org. Chem. Front.,2019, 6, 3891-3895

12.H. W. Zhao,*W. Q. Ding, J. M. Guo, et al. Formal [4+2] Cycloaddition of Vinyl Benzoxazinones with Oxazol-5-(4H)-ones for Diastereoselective Construction of 3,4-Disubstituted Dihydro-2(1H)-Quinolinones,Adv. Synth.& Catal.,2019, 361(17),4111-4116

13.H. W. Zhao,*L. R. Wang, J. M. Guo, et al. Formal [5+3] Cycloaddition of Vinylethylene Carbonates with Isatin-Based alpha-(Trifluoromethyl)imines for Diastereoselective Synthesis of Medium-Heterocycle-Fused Spirooxindoles,Adv. Synth.& Catal.,2019, 361(20), 4761-4771

14.Hong-Wu Zhao,* Juan Du, Jia-Ming Guo, Ning-Ning Feng, Li-Ru Wang,Wan-Qiu Ding and Xiu-Qing Song,Formal [5+2] cycloaddition of vinylethylene carbonates to oxazol-5-(4H)-ones for the synthesis of 3,4-dihydrooxepin-2(7H)-ones,Chem. Commun.,2018, 54, 9178–9181

15.Hong-Wu Zhao,* Ning-Ning Feng, Jia-Ming Guo, Juan Du, Wan-Qiu Ding, Li-Ru Wang,and Xiu-Qing Song Diastereoselective and Enantioselective Synthesis of Barbiturate-Fused Spirotetrahydroquinolines via Chiral Palladium(0)/Ligand Complex Catalyzed [4 + 2] Cycloaddition of Vinyl Benzoxazinanones with Barbiturate-Based Olefins,J. Org. Chem.,2018, 83, 9291-9299

16.Hong-Wu Zhao,* Yue-Yang Liu, Yu-Di Zhao,Ning-Ning Feng,Juan Du, Xiu-Qing Song, Hai-Liang Pang, Xiao-Qin Chen, Base-catalyzed [3+2] Cycloaddition of Diazooxindoles with Oxazol-5-(4H)-ones for Synthesis of Novel 3-(1H-1,2,4-triazol-1-yl)indolin-2-ones,Eur. J. Org. Chem.,2018,2017,341-346

17.Hong-Wu Zhao,* Yu-Di Zhao, Yue-Yang Liu, Li-Jiao Zhao,Xiu-Qing Song, Xiao-Qin Chen, Hai-Liang Pang, Juan Du and Ning-Ning Feng, 1,3-Dipolar [3 + 3] cycloaddition of ahalohydroxamate-based azaoxyallyl cations with hydrazonoyl chloride-derived nitrile imines,RSC Adv.,2017, 7, 55106–55109

18.Hong-Wu Zhao,*Xiao-Qin Chen, Yu-Di Zhao, Yue-Yang Liu, Hai-Liang Pang, Xiu-Qing Song, TingTian, Bo Li, Zhao Yang, Juan Du, Ning-Ning Feng, [3+2] Cycloaddition Between3-Isothiocyanato Oxindoles and Nitroso Compounds,Eur. J. Org. Chem.,2017,2017,3139-3144,

19.Hong-Wu Zhao,*Yu-Di Zhao, Yue-Yang Liu, Juan Du, Hai-Liang Pang, Xiao-Qin Chen, Xiu-QingSong, Ning-Ning Feng, Base-promoted [3+2] Cycloaddition of in situ formedAzaoxyallyl Cations with Isothiocyanides,Eur.J. Org. Chem.,2017,2017, 3466–3472

20.Hong-Wu Zhao,* Hai-Liang Pang, Yu-Di Zhao, Yue-Yang Liu, Li-Jiao Zhao, Xiao-Qin Chen, Xiu-Qing Song, Ning-Ning Feng and Juan Du,Construction of 2,3,4,5-tetrahydro-1,2,4-triazines via [4 + 2] cycloaddition of α-halogeno hydrazones to iminesRSC Adv.,2017,7, 9264-9271

21.Hong-Wu Zhao,* Yu-Di Zhao,Yue-Yang Liu, Li-Jiao Zhao,* Ning-NingFeng, Hai-Liang Pang, Xiao-Qin Chen, Xiu-Qing Song, Juan Du,A facile access to novel 1,2,4-oxadiazinan-5-ones via [3+3] cycloaddition of in situ generated azaoxyallyl cations with nitrones,RSC Adv.,2017,7, 12916-12922

22.Hong-Wu Zhao,* Yue-Yang Liu, Yu-Di Zhao, Hai-Liang Pang, Xiao-Qin Chen, Xiu-Qing Song, Ting Tian, Bo Li, Zhao Yang, Juan Du, Ning-Ning Feng,[3 + 2] Cycloaddition of Oxazol-5-(4H)-ones with Nitrones for Diastereoselective Synthesis of Isoxazolidin-5-ones,Org. Lett.,2017,19,26-29

23.Hong-Wu Zhao,* Hai-Liang Pang, Ting Tian, Bo Li, Xiao-Qin Chen, Xiu-Qing Song, Wei Meng, Zhao Yang, Yue-Yang Liu, Yu-Di Zhao, Construction of 2,3,4,7-tetrahydro-1,2,4,5-oxatriazepine via [4+3] cycloaddition of α-halogenohydrazones with nitrones,Adv. Synth.& Catal.2016,358,1826–1832

24.Hong-Wu Zhao,* Bo Li, Hai-Liang Pang, Ting Tian,Xiao-Qin Chen, Xiu-Qing Song, Wei Meng, Zhao Yang, Yu-Di Zhao, Yue-Yang Liu,Diastereoselective1,3-dipolar cycloadditions of N, N’-cyclic azomethine imines with iminooxindoles foraccess to oxindole-spiro-N,N-bicyclic heterocycles,Org. Lett.2016,18,848-851

25.Hong-Wu Zhao,* Hai-Liang Pang, Bo Li, Ting Tian, Xiao-Qin Chen, Xiu-Qing Song, Wei Meng, Zhao Yang, Yue-Yang Liu, Yu-Di Zhao, Direct Access to Non-Aromatic 1,2,3,6-Tetrahydro -1,2,3,4-Tetrazines via [4+2] Cycloaddition of α-HalogenoHydrazones with AzodicarboxylicAcid Derivatives,RSC Adv.2016,6, 25562-25567

26.Hong-Wu Zhao,* Ting Tian, Hai-Liang Pang, Bo Li, Zhao Yang, Wei Meng, Xiu-Qing Song,Xiao-Qin Chen, Organocatalytic [3+2] Cycloaddition of Barbiturate-Based Olefinswith 3-Isothiocyanato Oxindoles: Highly Diastereoselective and Enantioselective Synthesis of Dispirobarbiturates,Adv. Synth. & Catal.2016,358, 2619-2630

27.Hong-Wu Zhao,* Bo Li, Ting Tian, Xiu-Qing Song, Hai-Liang Pang, Xiao-Qin Chen, Zhao Yang, Wei Meng, Facile construction of novel imidazolidine-spirooxindoles via diastereoselectivecycloaddition of N-acylhydrazine-derived imines with 3-isothiocyanato oxindoles,RSC Adv.2016,6, 27690-27695

28.Hong-Wu Zhao,* Xiao-Qin Chen,Hai-Liang Pang,Ting Tian,Bo Li,Xiu-Qing Song,Wei Meng,Zhao Yang,Yu-Di Zhao,Yue-Yang Liu, Diastereoselective synthesis of highly functionalized polycyclic benzosultams via tandem cyclisationsof cyclic N-sulfonylimineswith in situ generatedHuisgen 1,4-dipoles,RSC Adv.2016,6, 61732-61739

29.Zhao, H.-W.;* Tian, T.; Li, B.; Yang, Z.; Pang, H.-L.; Meng, W.; Song, X.-Q.; Chen, X.-Q., Diastereoselective Synthesis of Dispirobarbiturates through Et3N-Catalyzed [3 + 2] Cycloaddition of Barbiturate-Based Olefins with 3-Isothiocyanato Oxindoles.J. Org. Chem.2015,80, 10380-10385

30.Zhao, H.-W.;*Chen, X.-Q.; Yang, Z.; Tian, T.; Li, B.; Meng, W.; Song, X.-Q.; Pang, H.-L., Highly diastereoselective synthesis of imidazolidine-dispirooxindoles via three-component [3 + 2] cycloadditions of isatins, 2-(aminomethyl)pyridine and isatin-based imines.RSC Adv.2015,5, 103116-103122

31.Zhao, H.-W.;* Yang, Z.; Meng, W.; Tian, T.; Li, B.; Song, X.-Q.; Chen, X.-Q.; Pang, H.-L., Diastereo- and Enantioselective Synthesis of Chiral Pyrrolidine-Fused Spirooxindoles via Organocatalytic [3+2] 1,3-Dipolar Cycloaddition of AzomethineYlides with Maleimides.Adv. Synth. & Catal.2015,357, 2492-2502

32.Zhao, H.-W.;*Li, B.; Tian, T.; Meng, W.; Yang, Z.; Song, X.-Q.; Chen, X.-Q.; Pang, H.-L., Highly Enantioselective Synthesis of Chiral Pyranonaphthoquinone-Fused Spirooxindoles through Organocatalytic Three-Component Cascade Reactions.Eur. J. Org. Chem.2015,2015, 3320-3326

33.Paul R. Carlier,*Hongwu Zhao, Stephanie L. MacQuarrie-Hunter, Joseph C. DeGuzman, and Danny C. Hsu,Enantioselective Synthesis of Diversely Substituted Quaternary 1,4-Benzodiazepin-2-ones and 1,4-Benzodiazepine-2,5-diones.J. Am. Soc. Chem.2006,128, 15215-15220

34.Paul R. Carlier,*Hongwu Zhao, Joe DeGuzman, and Polo C.-H. Lam.Enantioselective Synthesis of “Quaternary” 1,4-Benzodiazepin-2-one Scaffolds via Memory of Chirality.J. Am. Chem. Soc.2003,125, 11482-11483

35.Hongwu Zhaoand Wenting Hua.*Synthesis and Characterization of Pyridine-Based Polyamido-Polyester Optically Active Macrocycles and Enantiomeric Recognition for d- and l-Amino Acid Methyl Ester Hydrochloride.J. Org. Chem.2000, 65, 2933-2938

二、国家发明专利

1.一种3,4-二氢氧基-2(7H)-酮及制备方法,申请号:201810449534.0,第一发明人, 已授权

2.一种八元氮氧杂环螺吲哚酮化合物及制备方法,申请号:201811028971.1,第一发明人, 已授权

3.一种手性3,4-二氢-2(1H)-喹啉酮类化合物及制备方法,申请号: 201811574684.0,第一发明人, 已授权

4.一种手性巴比妥螺四氢喹啉类化合物及制备方法,申请号:201810449570.7, 第一发明人, 已授权

5.一种手性1,4-苯并二氮卓-2-酮螺杂环化合物及制备方法,申请号:202011442438.7,第一发明人, 实审阶段

6.一种氮杂中环内酯化合物及制备方法,申请号:202011441268.0,第一发明人,实审阶段

7.一种手性螺环吡唑啉酮化合物及制备方法,申请号:202110058934.0,第一发明人,实审阶段

8.一种手性噁二嗪杂环稠合1,4-苯并二氮卓-2-酮类化合物及制备方法,申请号:202110113673,第一发明人,实审阶段

9.一种巴比妥类化合物及制备方法,申请号:202111220439.1,第一发明人,实审阶段

10.一种手性三嗪杂环螺合1,4-苯并二氮卓-2-酮化合物及制备方法,申请号:202111460734.4,第一发明人,实审阶段

11.一种多官能团化的吡唑酮类化合物及制备方法,申请号:202210058957.6,第一发明人,实审阶段

12.一种多官能化氮杂双烯类化合物及制备方法,申请号:202210050769.9,第一发明人,实审阶段

学校地址:北京市朝阳区平乐园100号
邮政编码:100124

  • 北京工业大学
    研究生招生

  • 北京工业大学
    研究生教育

Copyright © 北京工业大学研究生院版权所有