胡利明

职称职务:教授,博士生导师

E-mail:huliming@bjut.edu.cn

通讯地址:北京市朝阳区平乐园100号北京工业大学生命科学院(100124)

基本信息

胡利明,1963年9月生,博士,教授,博士生导师。分别于1985年和1994年在华中师范大学获得理学学士和硕士学位;2001年在武汉大学获得理学博士学位。先后在武汉教育学院和华中师范大学从事教学和科研工作;2002年进入厦门大学福建省化学生物学重点实验室从事博士后研究;2004年进入北京工业大学,现为北京工业大学生命科学与生物工程学院教授。

研究方向

(1)药物合成方法学研究与新技术应用;

(2)计算机辅助药物设计与虚拟筛选;

(3)蛋白质与配体的相互作用与识别以及构效关系的研究;

(4)具有生物活性的有机磷化学研究;

(5)天然药物中有效成分的提取、鉴定和活性研究

在研项目(主持,2010年)

(1)国家重大科学研究计划项目(2009.1-2013.12):载药纳米颗粒的药效学、生物利用度及其机理研究;

(2)北京市人才强教项目:HIV与靶细胞融合过程的小分子抑制剂研究;

(3)北京市基金(2010.1-2012.12):以gp41为靶标的抗HIV-1药物先导体研究。

研究成果

自2001年以来,主持和参与研究项目二十多项,包括国家重大科学研究计划项目、国家科技攻关项目、国家自然科学基金项目、教育部重点科技项目、博士后基金项目、北京市教委科技项目、北京市人才强教项目、北京市基金项目、湖北省重点科技项目、福建省重大科技项目、福建省重点科技项目和福建省自然科学基金项目等;获得湖北省科技进步二等奖(1999)和北京市中青年骨干教师;在各级、类刊物中发表研究性学术论文100余篇,其中有35篇被SCI收录;授权专利6件(其中美国专利1项);作为主要研究者获得国家三类新药证书1项、国家重点新产品证书1项、国家食品药品监督管理局原料药和制剂注册批件各1件。

近三年来发表的学术论文

1. Xiaowei Ma, Dongliang Wang,Yan Wu, Rodney J. Y. Ho, Lee Jia, Peixuan Guo,Liming Hu,Gengmei Xing,Yi Zeng, Xing-Jie Liang, AIDS Treatment with Novel Anti-HIV Compounds Improved

by Nanotechnology,The AAPS Journal, 2010,12(3), 272-278

2. Cheng-Chu Zeng,Da-Wei Ping,Li-Ming Hu, Xiu-Qing Song, Ru-Gang Zhong, Anodic oxidation of catechols in the presence of a-oxoketene N,N-acetals with a tetrahydropyrimidine ring: selective a-arylation reaction,Organic & Biomolecular Chemistry,2010, 8: 2465–2472

3. Leifu Yang, Xuemei Xu, Yali Huang, Bin Zhang, Chengchu Zeng, Hongqiu He, Cunxin Wang,Liming Hu, Synthesis of polyhydroxylated aromatics having amidation of piperazine

nitrogen as HIV-1 integrase inhibitor,Bioorganic & Medicinal Chemistry Letters, 2010,20:5469–5471

4. Lin Yang , Liqiang Chen , Rong Zeng , Chao Li , Renzhong Qiao ,Liming Hu, Zelin Li, Synthesis, nanosizing and in vitro drug release of a novel anti-HIV polymeric prodrug: Chitosan-O-isopropyl-5- O-d4T monophosphate,Bioorganic & Medicinal Chemistry,2010,18:117-123

5. Jian J. Tan, Xiao J. Cong,Li M. Hu, Cun X. Wang,Lee Jia and Xing-Jie Liang, Therapeutic strategies underpinning the development of novel techniques for the treatment of HIV infection,Drug Discovery Today, 2010, 15( 5/6), 186-197

6. LUO Zai-gang, ZENG Cheng-chu, WANG Fang, HE Hong-qiu, WANG Cun-xin, DU Hong- guang ,HU Li-ming, Synthesis and Biological Activities of Quinoline Derivatives as HIV-1 Integrase Inhibitors,CHEM. RES. CHINESE UNIVERSITIES,2009, 25(6), 841-845

7. Zeng CC, Ping DW, Xu YS,Hu, LMet al.,A Facile Synthesis of alpha-Aryl alpha-Oxo- heterocyclic Ketene N,N-Acetals Bearing an Electron-Rich Catechol Subunit-An Electrochemical Oxidative Approach,EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2009, 33: 5832-5840

8. Yang DS, Liu HX, Yang HJ,Hu, LMet al.Copper-Catalyzed Synthesis of 1,2,4-Benzothiadia- zine 1,1-Dioxide Derivatives by Coupling of 2-Halobenzenesulfonamides with AmidinesADVANCED SYNTHESIS & CATALYSIS, 2009,351(11-12):1999-2004

9. Zeng CC, Liu FJ, Ping DW,Hu, LMet al.One-Pot Electrochemical Synthesis of Fused Indole Derivatives Containing Active Hydroxyl Groups in Aqueous Medium,JOURNAL OF ORGANIC CHEMISTRY,2009, 74(16): 6386-6389

10. Luo ZG, Zeng CC, Yang DS,Hu, LMet al.Electrospray Ionization Mass Spectra of Dipeptide DerivativesCHINESE JOURNAL OF CHEMISTRY,2009,27(7): 1333-1338

11. Zeng J, Lu XH, Zeng CC,Hu, LMet al.,Design, Synthesis and Anti-HIV Integrase Evaluation of 1,2,3-Triazol-4-yl-substituted 1,4-Dihydro-4-oxo-1,5-napthyridine-3-carboxylic Acids,CHINESE JOURNAL OF CHEMISTRY, 2009, 27( 5): 953-962

12. Zeng CC, Liu FJ, Ping DW,Hu, LMet al.,Electrochemical synthesis of 1,3,4-thiadiazol-2- ylthio-substituted catechols in aqueous medium,TETRAHEDRON, 2009, 65(23): 4505-4512

13. Luo ZG, Zeng CC, Yang LF,Hu, LMet al.,Synthesis of 6-sulfamoyl-4-oxoquinoline-3- carboxylic acid derivatives as integrase antagonists with anti-HIV activity,CHINESE CHEMICAL LETTERS,2009, 20( 7): 789-792

14. Yang DS, Fu H,Hu LM, et al.,Environmentally Friendly Iron-Catalyzed Cascade Synthesis of 1,2,4-Benzothiadiazine 1,1-Dioxide and Quinazolinone Derivatives,JOURNAL OF COMBINATORIAL CHEMISTRY, 2009,11( 4): 653-657

15. Yang, L; Zeng, R ;Li, C;Li, G;Qiao, RZ;Hu, LM;Li, ZL, Novel synthesis and in vitro drug release of polymeric prodrug: Chitosan-O-isopropyl-5 '-O-d4T monophosphate conjugate,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2009,19(9): 2566-2569

16. Xu YS, Zeng CC,Jiao, ZG,Hu LM, Zhong RG, Design, Synthesis and Anti-HIV Integrase Evaluation of 4-Oxo-4H-quinolizine-3- carboxylic Acid Derivatives,MOLECULES,2009,14(2): 868- 883

17. Yang DS, Fu H,Hu LM,Jiang YY, Zhao, YF, Copper-catalyzed synthesis of benzimidazoles via cascade reactions of o-haloacetanilide derivatives with amidine hydrochlorides,JOURNAL OF ORGANIC CHEMISTRY, 2008,73(19):7841-7844

18.Hu LM, Wu J, Li XP, Xu HS, Investigation of plant systemic organoseleno compounds. V. Effects of the derivatives of selenomorpholine on the selenium content of garlic,JOURNAL OF PLANT NUTRITION, 2008,31(9):1570-1577

19. Wang F,Hu LM, Li, XP, Xu XM, Du HG, Synthesis of O,O-dialkyl 2-oxo-2-(4-(selenomorpho- linosulfonyl)phenylamino) ethylphosphonate,PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS,2008,183(2-3):610- 616

学校地址:北京市朝阳区平乐园100号
邮政编码:100124

  • 北京工业大学
    研究生招生

  • 北京工业大学
    研究生教育

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