基本情况

   孙国辉，男，1989年8月生，安徽合肥人，中共党员，博士，教授，博士生导师。现任北京工业大学化学与生命科学学院副院长。

2017年毕业于北京工业大学生命学院，获生物医学工程专业博士学位（导师：钟儒刚 教授）。环境科学与工程流动站博士后（合作导师：彭永臻 院士）；兼任中国药学会高级会员、美国化学会会员、中国化学会会员、中国药理学会会员和中国生物医学工程学会会员等学术职务。入选2022北京市属高校优秀青年人才计划。2024年破格晋升教授。

主持和参与的科研项目包括国家自然科学基金、北京市自然科学基金、中国博士后科学基金和北京市博士后科学基金等。目前以第一作者或通讯作者发表SCI论文42篇（ESI高被引4篇），申请及获批国家发明专利多项。担任多个SCI期刊审稿人。曾获博士研究生国家奖学金、北京工业大学校长奖学金、科技之星、优秀博士学位论文；2019和2020年MDPI出版社杰出审稿人代表奖。

担任SCI期刊Scientific Reports (IF:3.8)编辑、Frontiers in Bioscience-Landmark (IF：3.1)、World Journal of Clinical Oncology (IF:2.8)和Molecular and Clinical Oncology (IF:1.2)编委；担任SCI期刊Molecules（IF：4.6，专刊Molecular Toxicology and Cancer Prevention）、Frontiers in Molecular Bioscience (IF:5.0，专刊New Progress in Cancer Biomarkers and Therapy)和Cells（IF：6.0，专刊Tumor Metabolism and Therapy）客座编辑。

担任中文核心期刊《化学试剂》青年编委

研究方向

分子毒理与应用药理学。围绕癌症防治工作，重点开展DNA抗癌烷化剂的作用机理及耐药性调控研究，以及药物分子及相关化合物的毒性、突变性及致癌性机理和构效关系研究。具体研究工作有以下几个方面：

1. DNA抗癌烷化剂的作用机理研究：寻找肿瘤化疗的生物标志物，设计高活性抗癌烷化剂。

2. 化疗药物的耐药性调控研究：研发高效低毒的化疗增敏剂，提高化疗药物抗肿瘤效果。

3. 分子毒理学：主要研究药物相关分子及污染物的构效关系，对人体健康和环境风险评估具有重要的指导意义。

主持和参与的课题

1. 基于“HLAGR” 耐药调控机制的新型3-溴丙酮酸前药的设计、 合成与生物活性评价，北京市自然科学基金(2024.1-2026.12)，No. 7242193，主持。

2. 基于嘌呤和嘧啶核心骨架的肿瘤靶向性MGMT抑制剂的设计、合成与生物活性评价，国家自然科学基金(2021.01-2023.12)，No.82003599，主持。

3. 糖酵解抑制剂对氯乙基亚硝基脲耐药性的调控机制研究，北京市教委科技计划一般项目(2021.01-2023.12)，No. KM202110005005，主持。

4. 3-溴丙酮酸与氯乙基亚硝基脲联合用药的抗肿瘤活性及其作用机制研究，北京市自然科学基金青年基金(2018.01-2019.12)，No.7184192，主持。

5. 能量代谢抑制剂 3-溴丙酮酸联合亚硝基脲的抗癌活性研究，中国博士后基金面上项目(2017.12-2019.08)，No. 2017M620567，主持。

6. 北京市博士后工作基金 (2018.07-2019.08)，No. 2018-ZZ-022，主持。

7. 3-溴丙酮酸逆转神经胶质瘤亚硝基脲耐药性的作用机理研究，朝阳区博士后基金(2018.12-2019.08)，No. 2018ZZ-01-25，主持。

8. 北京工业大学博士科研启动基金，2020.01-2020.12，主持。

9. 低氧激活联合亚硝基脲的作用机理及抗癌活性研究，国家自然科学基金面上项目(2018.01-2021.12)，No. 21778011，参与。

代表性研究论文和专利

【2024年】

[1] Chen, S.; Fan, T.J.; Zhang, N.; Zhao, L.J.; Zhong, R.G.; Sun, G.H* The oral acute toxicity of per- and polyfluoroalkyl compounds (PFASs) to Rat and Mouse: A mechanistic interpretation and prioritization analysis of untested PFASs by QSAR, q-RASAR and interspecies modelling methods. Journal of Hazardous Materials 2024, 480, 136071. (IF: 12.2, JCR1区，通讯作者)

[2] Wu, T.; Liu, Y.; Zhou, S.; Li, J.; Sun, G.H.*; Gu, B.*; Wang, C.W* Wheat Germ Agglutinin-Modified “Three-in-One” Multifunctional Probe Driven Broad-Spectrum and Flexible Immunochromatographic Diagnosis of viruses With High Sensitivity. Small, 2024, 2406053. (IF: 13.0, JCR 1区，通讯作者)

https://doi.org/10.1002/smll.202406053

[3] Chen, S.; Fan, T.J.; Ren, T.; Zhang, N.; Zhao, L.J.; Zhong, R.G.; Sun, G.H* High-throughput prediction of oral acute toxicity in Rat and Mouse of over 100,000 polychlorinated persistent organic pollutants (PC-POPs) by interpretable data fusion-driven machine learning global models. Journal of Hazardous Materials 2024, 480, 136295. (IF: 12.2, JCR1区，通讯作者)

[4] Tang, Q.; Ren, T.; Bai, P.Y.; Wang, X.; Zhao, L.J.; Zhong, R.G.; Sun, G.H* Novel strategies to overcome chemoresistance in human glioblastoma. Biochemical Pharmacology 2024, 230, 116588. (IF: 5.8, JCR 1区，通讯作者)

[5] Wang, Y.T.; Wang, P.; Fan, T.J.; Ren, T.; Zhang, N.; Zhao, L.J.; Zhong, R.G.; Sun, G.H* From molecular descriptors to the developmental toxicity prediction of pesticides/veterinary drugs/bio-pesticides against zebrafish embryo: Dual computational toxicological approaches for prioritization. Journal of Hazardous Materials 2024, 476, 134945. (IF: 12.2, JCR1区，通讯作者)

[6] Li, F.F.; Wang, P.; Fan, T.J.; Zhang, N.; Zhao, L.J.; Zhong, R.G.; Sun G.H.* Prioritization of the ecotoxicological hazard of PAHs towards aquatic species spanning three trophic levels using 2D-QSTR, read-across and machine learning-driven modelling approaches, Journal of Hazardous Materials, 2024, 465, 133410. (IF: 12.2, JCR1区，通讯作者)

[7] Huang, Y., Wang, P., Fan, T., Zhang, N., Zhao, L., Zhong, R., Sun, G. H.* Energy blocker lonidamine reverses nimustine resistance in human glioblastoma cells through energy blockade, redox homeostasis disruption, and O6-methylguanine-DNA methyltransferase downregulation: in vitro and in vivo validation. ACS Pharmacology & Translational Science 2024, 7(5), 1518-1532. (IF: 6.0，JCR1区，通讯作者)

[8] Lu, X., Wang, X., Chen, S., Fan, T., Zhao, L., Zhong, R., Sun, G. H*. The rat acute oral toxicity of trifluoromethyl compounds (TFMs): a computational toxicology study combining the 2D-QSTR, read-across and consensus modeling methods. Archives of Toxicology, 2024, 98, 2213–2229 (IF: 6.1，JCR1区，通讯作者)

[9] Wang, Q.Q.; Fan, T.J.; Jia, R.Q.; Zhang, N.; Zhao, L.J.; Zhong, R.G.; Sun, G.H.* First report on the QSAR modelling and multistep virtual screening of the inhibitors of nonstructural protein Nsp14 of SARS-CoV-2: Reducing unnecessary chemical synthesis and experimental tests. Arabian Journal of Chemistry 2024, 17(3), 105614. (IF: 6.0, JCR2区，通讯作者)

[10] Wang, Q.Q.; Lu, X.Y.; Jia, R.Q.*; Yan, X.L.*; Wang, J.H.*; Zhao, L.J.; Zhong, R.G.; Sun, G.H.* Recent advances in chemometric modelling of inhibitors against SARS-CoV-2. Heliyon, 2024, 10, e24209. (IF: 4.0, JCR2区，通讯作者)

[11] Li, Y.S.; Fan, T.J.; Ren, T.; Zhang, N.; Zhao, L.J.; Zhong, R. G.; Sun, G. H.* Ecotoxicological risk assessment of pesticides against different aquatic and terrestrial species: using mechanistic QSTR and iQSTTR modelling approaches to fill toxicity data gap. Green Chemistry, 2024, 26, 839–856. (IF: 9.8, JCR1区，通讯作者) (ESI高被引)

[12] Fan, T.J.; Shen, L.; Huang, Y. X.; Wang, X.*; Zhao, L. J.; Zhong, R. G.; Wang, P.*; Sun, G. H.* Lonidamine increases the cytotoxic effect of 1-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-3-(2-chloroethyl)-3-nitrosourea via energy inhibition, disrupting redox homeostasis, and downregulating MGMT expression in human lung cancer cell line. ACS Omega 2024, 9 (34), 36134-36147. (IF: 3.7, JCR2区，第一/通讯作者)

[13] Sun, G.H.*; He, C.W.*; Wang, J.H.* Editorial: New progress in cancer biomarkers and therapy. Frontiers in Molecular Biosciences, 2024, 11, 1388872. (IF: 3.9, JCR2区，第一/通讯作者)

【2023年】

[1] Bai, P. Y.; Fan, T. J.; Wang, X.; Zhao, L. J.; Zhong, R. G.; Sun, G. H.* Modulating MGMT expression through interfering with cell signaling pathways. Biochemical Pharmacology, 2023, 215, 115726. (IF: 5.8, JCR 1区，通讯作者)

[2] Sun, G. H.*; Bai, P. y.; Fan, T. J.; Zhao, L. J.; Zhong, R. G.; McElhinney, R. S.; McMurry, T. B. H.; Donnelly, D. J.; McCormick, J. E.; Kelly, J.; Margison, G. P.* QSAR and chemical read-across analysis of 370 potential MGMT inactivators to identify the structural features influencing inactivation potency. Pharmaceutics, 2023, 15(8), 2170. (IF: 5.4, JCR 1区，第一/通讯作者)

[3] Sun, G.H.*; Wang, C.W.* Molecular toxicology and cancer prevention. Molecules, 2023, 28, 7730. (IF: 4.6, JCR2区, 第一/通讯作者)

[4] Chen, S.; Sun, G. H.*; Fan, T. J.; Li, F. F.; Xu, Y. C.; Zhang, N.; Zhao, L. J.; Zhong, R. Ecotoxicological QSAR study of fused/non-fused polycyclic aromatic hydrocarbons (FNFPAHs): Assessment and priority ranking of the acute toxicity to Pimephales promelas by QSAR and consensus modeling methods. Science of the Total Environment 2023, 876, 162736. (IF: 9.8, JCR 1区) (通讯作者) (ESI高被引)

[5] Tu, J.; Wu, T.; Yu, Q.; Li, J. X.; Zheng, S.; Qi, K. Z.; Sun, G. H.*; Xiao, R.*; Wang, C. W.* Introduction of multilayered magnetic core–dual shell SERS tags into lateral flow immunoassay: A highly stable and sensitive method for the simultaneous detection of multiple veterinary drugs in complex samples. Journal of Hazardous Materials, 2023, 448, 130912. (IF: 13.6, JCR 1区) (通讯作者) (ESI高被引)

[6] Bai, P. Y.; Fan, T. J.; Sun, G. H.*; Wang, X.; Zhao, L. J.; Zhong, R. G. The dual role of DNA repair protein MGMT in cancer prevention and treatment. DNA Repair, 2023, 123, 103449. (IF: 3.8，JCR 2区) (通讯作者)

[7] Li, F. F.; Sun, G. H.*; Fan, T. J.; Zhang, N.; Zhao, L. J.; Zhong, R. G.; Peng, Y. Z. Ecotoxicological QSAR modelling of the acute toxicity of fused and non-fused polycyclic aromatic hydrocarbons (FNFPAHs) against two aquatic organisms: Consensus modelling and comparison with ECOSAR. Aquatic Toxicology 2023, 255, 106393. (IF: 4.5, JCR 1区) (通讯作者) (ESI高被引)

【2022年】

[1] Hao, Y. X.; Fan, T. J.; Sun, G.H.*; Li, F. F.; Zhang, N.; Zhao, L. J.; Zhong, R. G. Environmental toxicity risk evaluation of nitroaromatic compounds: Machine learning driven binary/multiple classification and design of safe alternatives. Food and Chemical Toxicology, 2022, 170, 113461. (IF: 4.3, JCR 1区) (通讯作者)

[2] Li, F.F.; Fan, T.J.; Sun, G.H.*; Zhao, L.J.; Zhong, R.G.; Peng, Y.Z. Systematic QSAR and iQCCR modelling of fused/non-fused aromatic hydrocarbons (FNFAHs) carcinogenicity to rodents: reduce unnecessary chemical synthesis and animal testing. Green Chemistry, 2022, 2022, 24, 5304. (IF: 9.8, JCR 1区) (通讯作者)

[3] Sun, X.D.; Fan, T.J.; Sun, G.H.*; Zhou, Y.; Huang, Y.X.; Zhang, N.; Zhao, L.J.; Zhong, R.G.; Peng, Y.Z. 2-Deoxy-D-glucose increases the sensitivity of glioblastoma cells to BCNU through the regulation of glycolysis, ROS and ERS pathways: In vitro and in vivo validation. Biochemical Pharmacology, 2022, 199, 115029. (IF: 5.8, JCR 1区) (通讯作者)

【2021年】

[1] Sun, G.H.*; Zhang, Y.F.; Pei, L.Y.; Lou, Y.Q.; M, Y.; Yun, J.Y.; Li, F.F.; Wang, Y.C.; Hao, Z.Q.; Xi, S.; Li, C.; Chen, C.H.; Zhao, L.J.*; Zhang, N.; Zhong, R.G.; Peng, Y.Z. Chemometric QSAR modeling of acute oral toxicity of Polycyclic Aromatic Hydrocarbons (PAHs) to rat using simple 2D descriptors and interspecies toxicity modeling with mouse. Ecotoxicology and Environmental Safety, 2021, 222, 112525. (IF: 6.8, JCR 1区) (第一/通讯作者)

[2] Huang, T.; Sun, G.H.*; Zhao, L.J.; Zhang, N.; Zhong, R.G.; Peng, Y.Z. Quantitative Structure-Activity Relationship (QSAR) studies on the toxic effects of nitroaromatic compounds (NACs): A systematic review. International Journal of Molecular Sciences, 2021, 22, 8557. (IF:5.6, JCR 1区) (通讯作者)

[3] Zhang, C.; Hong, L.; Ma, N.*; Sun, G. H.* Logic analysis of how the emergency management legal system used to deal with public emerging infectious diseases under balancing of competing interests—the case of COVID-19. Healthcare, 2021, 9, 857. (IF:3.16, JCR 2区) (通讯作者)

[4] Ma, N.; Ma, S.; Li, S. J.; Ma, S.*; Pan, X. Z.; Sun, G. H.* The study of spatial safety and social psychological health features of deaf children and children with an intellectual disability in the public school environment based on the visual access and exposure (VAE) model. International Journal of Environmental Research and Public Health, 2021, 18(8), 4322. (IF: 4.614, JCR 1区) (通讯作者)

【2020年】

[1] Hao, Y. X.; Sun, G. H.*; Fan, T. J.; Tang, X. Y.; Zhang J.; Liu, Y. D.; Zhang, N.; Zhao, L. J.; Zhong, R. G.; Peng, Y. Z. In vivo toxicity of nitroaromatic compounds to rats: QSTR modelling and interspecies toxicity relationship with mouse. Journal of Hazardous Materials, 2020, 399, 122981. (IF: 13.6, JCR 1区) (通讯作者)

[2] Huang, Y. X.; Sun, G. H.*; Sun, X. D.; Li, F. F.; Zhao, L. J.; Zhong, R. G.; Peng, Y. Z. The potential of lonidamine in combination with chemotherapy and physical therapy in cancer treatment. Cancers, 2020, 12, 3332. (IF: 5.2, JCR 2区) (通讯作者)

[3] Sun, X. D.; Sun, G. H.*; Huang, Y. X.; Hao Y. X.; Tang, X. Y.; Zhang, N.; Zhao, L. J.; Zhong, R. G.; Peng, Y. Z. 3-Bromopyruvate regulates the status of glycolysis and BCNU sensitivity in human hepatocellular carcinoma cells. Biochemical Pharmacology, 2020, 177, 113988. (IF: 5.8, JCR 1区) (通讯作者)

[4] Sun, X. D.; Sun, G. H.*; Huang, Y. X.; Zhang, S. F.; Tang, X. Y.; Zhang, N.; Zhao, L. J.; Zhong, R. G.; Peng, Y. Z. Glycolytic inhibition by 3-bromopyruvate increases the cytotoxic effects of chloroethylnitrosoureas to human glioma cells and the DNA interstrand cross-links formation. Toxicology, 2020, 435, 152413. (IF: 4.5, JCR 1区) (通讯作者)

【2019年】

[1] Hao, Y. X.; Sun, G. H.*; Fan, T. J.; Sun, X. D.; Liu, Y. D.; Zhang, N.; Zhao, L. J.; Zhong, R. G.; Peng, Y. Z. Prediction on the mutagenicity of nitroaromatic compounds using quantum chemistry descriptors based QSAR and machine learning derived classification methods. Ecotoxicology and Environmental Safety, 2019, 186, 109822. (IF: 6.8, JCR 1区) (通讯作者)

[2] Fan T. J.; Sun, G. H.*; Sun X. D.; Zhao, L. J.; Zhong, R. G.; Peng Y. Z. Tumor energy metabolism and potential of 3-bromopyruvate as an inhibitor of aerobic glycolysis: implications in tumor treatment. Cancers, 2019, 11, 317. (IF:5.2, JCR2区，Editor’s Choice) (通讯作者)

【2014-2018年】

[1] Sun, G. H.*; Fan, T. J.; Sun, X. D.; Hao, Y. X.; Cui, X.; Zhao, L. J.*; Ren, T.; Zhou, Y.; Zhong, R. G.; Peng, Y. Z. In silico prediction of O⁶-methylguanine-DNA methyltransferase inhibitory potency of base analogs with QSAR and machine learning methods. Molecules, 2018, 23, 2892. (IF:4.6, JCR 2区) (Feature Paper) (第一/通讯作者)

[2] Sun, G. H.; Zhao, L. J.*; Zhong, R. G.; Peng, Y. Z. The specific role of O⁶-methylguanine-DNA methyltransferase inhibitors in cancer chemotherapy. Future Medicinal Chemistry, 2018, 10, 1971-1996. (IF:4.2, JCR 2区) (第一作者)

[3] Sun, G. H.; Fan, T. J.; Zhao, L. J.*; Zhou, Y.; Zhong, R. G. The potential of combi-molecules with DNA-damaging function as anticancer agents. Future Medicinal Chemistry, 2017, 9, 403-435. (IF:4.2, JCR 2区) (第一作者)

[4] Sun, G. H.; Zhang, N.; Zhao, L. J.*; Fan, T. J.; Zhang, S. F.; Zhong, R. G. Synthesis and antitumor activity evaluation of a novel combi-nitrosourea prodrug: Designed to release a DNA cross-linking agent and an inhibitor of O⁶-alkylguanine-DNA alkyltransferase. Bioorganic & Medicinal Chemistry, 2016, 24, 2097-2107. (IF:3.5, JCR 1区) (第一作者)

[5] Sun, G. H.; Zhao, L. J.*; Fan, T. J.; Ren, T.; Zhong, R. G. Measurement of O⁶-alkylguanine-DNA alkyltransferase activity in tumour cells using stable isotope dilution HPLC-ESI-MS/MS. Journal of Chromatography B, 2016, 1033, 138-146. (IF:3.0, JCR 2区) (第一作者)

[6] Sun, G. H.; Fan, T. J.; Zhang, N.; Ren, T.; Zhao, L. J.*; Zhong, R. G. Identification of the structural features of guanine derivatives as MGMT inhibitors using 3D-QSAR modeling combined with molecular docking. Molecules, 2016, 21, 823. (IF:4.6, JCR 2区) (第一作者)

[7] Sun, G. H.; Zhao, L. J.*; Zhong, R. G. The induction and repair of DNA interstrand crosslinks and implications in cancer chemotherapy. Anti-Cancer Agents in Medicinal Chemistry, 2016, 16, 221-246. (IF:2.8) (第一作者, JCR 3区)

[8] Sun, G. H.; Zhao, L. J.*; Fan, T. J.; Li, S. S.; Zhong, R. G. Investigations on the effect of O⁶-benzylguanine on the formation of dG-dC interstrand cross-links induced by chloroethylnitrosoureas in human glioma cells using stable isotope dilution high-performance liquid chromatography electrospray ionization tandem mass spectrometry. Chemical Research in Toxicology, 2014, 27, 1253-1262. (IF:4.1, JCR 2区) (第一作者)

[9] Fan, T. J.†; Sun, G. H.†; Zhao, L. J.*; Cui, X.; Zhong, R. G. QSAR and classification study on prediction of acute oral toxicity of N-nitroso compounds. International Journal of Molecular Sciences, 2018, 19, 3015. (Co-first author, IF:5.6, JCR 1区，TOP期刊)

【专利等其他】

[1] 孙国辉，肖伟男，孙晓东，范腾蛟，赵丽娇，钟儒刚，彭永臻. 一种低氧靶向肿瘤细胞DNA修复酶MGMT抑制剂及其制备方法与应用. 国家发明专利(已授权). 专利号: ZL201811634039.3

[2] 孙国辉，黄雅馨，郝兆骐，李辰，王雅琛，锡莎，孙晓东，张娜，赵丽娇，钟儒刚. 硝基苯取代的O⁶-3-氨甲基苄基鸟嘌呤及其制备方法与应用. 国家发明专利(已授权). 专利号: ZL202010184141.9.

[3] 孙国辉，李非凡，陈硕，赵丽娇，钟儒刚. 一种基于 2D 分子描述符的 PAHs 致癌性预测方法及预测模型. 国家发明专利. 申请号: CN202210115726.4

[4] 孙国辉, 陈硕, 范腾蛟, 赵丽娇, 钟儒刚. 一种基于 2D 分子描述符的 PFASs 口服急性毒性预测方法和预测模型. 国家发明专利. 申请号: CN202310879989.7

[5] 赵丽娇, 孙国辉, 钟儒刚. 一种新型的β-氯乙基亚硝基脲类化合物及其合成方法和用途. 国家发明专利(已授权). 专利号: ZL201410231997.1

[6] 陈硕，李非凡，孙国辉*，赵丽娇，钟儒刚. QSAR建模及其在抗病毒药物设计与筛选中的研究进展. 化学试剂. 2021, 43(7), 895~905. (通讯作者)

招生方向

博士：0857资源与环境

硕士：0703 化学(04方向：化学生物学); 0710生物学 (02 方向：肿瘤学与生物治疗)；0860生物与医药（专业学位）；0854电子信息/生物医学工程（专业学位）；

欢迎对我的研究方向感兴趣，踏实乐观、能吃苦、有团队精神和责任意识的新时代青年学生加入！！！

联系方式

北京市朝阳区平乐园100号

北京工业大学化学与生命科学学院 (生命楼B214)

邮政编码：100124

E-mail: sunguohui@bjut.edu.cn