基本信息

研究方向

1.多肽复合金属纳米材料在血液肿瘤、自身免疫疾病和神经退行性疾病中的生物药学活性评价与优化设计；

2.金属纳米材料在疾病治疗中发挥生物医学活性的机制分析与靶点鉴定。

主要科研成果

1. Gold Clusters Prevent Inflammation-Induced Bone Erosion through Inhibiting the Activation of NF-κB Pathway [J]. Theranostics, 2019, 9(7): 1825-1836.

2. Au nanoclusters suppress chronic lymphocytic leukaemia cells by inhibiting thioredoxin reductase 1 to induce intracellular oxidative stress and apoptosis [J]. Science Bulletin, 2017, 62(8): 537.

3. Peptide protected gold clusters: chemical synthesis and biomedical applications [J]. Nanoscale, 2016, 8(24): 12095-12104.

4. Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with reduced myelosuppression toxicity [J]. International Journal of Nanomedicine, 2014, 9: 4829-4846.

5. Cytotoxicity and therapeutic effect of irinotecan combined with selenium nanoparticles [J]. Biomaterials, 2014, 35(31): 8854-8866.

6. The suppression of prostate LNCaP cancer cells growth by Selenium nanoparticles through Akt/Mdm2/AR controlled apoptosis [J]. Biomaterials, 2011, 32(27): 6515-6522.

研究方向

1.生物医药活性金属纳米药物开发与靶向递送；

2.贵金属纳米团簇在恶性肿瘤和免疫疾病诊疗中的应用与优化设计；

3. 金属纳米材料免疫调控机制解析与功能化。

科研项目

1. 国家自然科学基金面上项目，多肽纳米金簇抑制肺部细胞因子风暴的生物效应研究，2022.01-2025.12，主持

2. 国家重点研发计划子课题，高分子纳米药物器官靶向适配规律及分子机制，2021.12-2026.11，项目骨干

3. 国家自然科学基金青年项目，多肽复合纳米金簇对慢性淋巴细胞白血病的生物活性研究及优化设计，2018.01-2020.12，主持

4. 北京市教育委员会科技计划一般项目，NF-kappa B拮抗肽组装纳米金簇用于弥漫大B细胞淋巴瘤多靶点协同治疗的基础研究，2021.01-2023.12，主持

获奖情况

北京工业大学优秀硕士论文指导教师

挑战杯全国大学生课外学术科技作品竞赛一等奖指导教师

全国大学生生命科学竞赛（科学探究类）三等奖指导教师

代表性研究成果

1. Lu, Cao; Xue, Liyuan; Luo, Kaidi;Liu,Yu; Lai, Jing; Yao, Xiuxiu; Xue, Yiling; Huo, Wendi; Meng, Cong; Xia, Dongfang; Gao, Xueyun;Yuan, Qing^*; Cao, Kai^*, Colon-Accumulated Gold Nanoclusters Alleviate Intestinal Inflammation and Prevent Secondary Colorectal CarcinogenesisviaNrf2-Dependent Macrophage Reprogramming.ACS Nano,2023,17(18), 18421-18432. (^*Corresponding author)

2. Meng, Cong; Liu, Yu; Ming, Yuping; Lu, Cao; Li, Yanggege; Zhang, Yulu; Su, Dongdong^*; Gao, Xueyun;Yuan, Qing^*, Enhancing Liver Delivery of Gold Nanoclusters via Human Serum Albumin Encapsulation for Autoimmune Hepatitis Alleviation.Pharmaceutics,2024,16(1), 110.

3. Lai, Jing^#;Yao, Yawen^#;Zhang, Yulu;Liu, Yu;Lu, Cao;Meng, Cong;Xia, Dongfang;Li, Yanggege;Cao, Kai;Gao, Xueyun^*;Yuan, Qing^*;Cell-Penetrating Peptide Conjugated Au Nanoclusters Selectively Suppress Refractory Lymphoma CellsviaTargeting Both Canonical and Noncanonical NF-κB Signaling Pathways.Bioconjugate chemistry, 2023,34(1), 228–237.

4.Chen, Xueqian; Niu, Wenchao;Yuan, Qing^*; Zhang, Yong; Gao, Xueyun; Su, Dongdong^*;Mapping the endogenous Zn2+ in situ during zebrafish embryogenesis by a fluorogenic sensor.Sensors and Actuators B: Chemical,2023,376, 132937.

5. Yao, Yawen; Lu, Cao; Gao, Liang; Cao, Kai; Yuan, Hui; Zhang, Xiangchun; Gao, Xueyun^*;Yuan, Qing^*; Gold Cluster Capped with a BCL-2 Antagonistic Peptide Exerts Synergistic Antitumor Activity in Chronic Lymphocytic Leukemia Cells.ACS applied materials & interfaces,2021,13(18), 21108-21118.

6. Zhang, Zhichao^#; Yao, Yawen^#;Yuan, Qing^*; Lu, Cao; Zhang, Xiangchun; Yuan, Jinling; Hou, Kaixiao; Zhang, Chunyu; Du, Zhongying; Gao, Xueyun^*; Chen, Xiongsheng^*; Gold clusters prevent breast cancer bone metastasis by suppressing tumor-induced osteoclastogenesis,Theranostics, 2020, 10(9): 4042-4055.

7.Yuan, Qing; Gao, Fuping; Yao, Yawen; Cai, Pengju; Zhang, Xiangchun; Yuan, Jinling; Hou, Kaixiao; Gao, Liang; Ren, Xiaojun; Gao, Xueyun*; Gold Clusters Prevent Inflammation-Induced Bone Erosion through Inhibiting the Activation of NF-kappa B Pathway,Theranostics, 2019, 9(7): 1825-1836.

8.Liu, Yu;Meng, Cong;Li, Yanggege;Xia, Dongfang;Lu, Cao;Lai, Jing;Zhang, Yulu;Cao, Kai;Gao, Xueyun^*;Yuan, Qing^*;Peptide-Protected Gold Nanoclusters Efficiently Ameliorate Acute Contact Dermatitis and Psoriasis via Repressing the TNF-α/NF-κB/IL-17A Axis in Keratinocytes.Nanomaterials,2023,13(4), 662.

9. Yuan, Jinling; Hou, Kaixiao; Yao Yawen; Du, Zhongying; Lu, Cao;Yuan, Qing^*; Gao, Xueyun^*; Gold Clusters Attenuate Inflammation in Rat Mesangial Cells via Inhibiting the Activation of NF-κB Pathway[J].Nanomaterials, 2020, 10(4):712.

10.Yuan, Qing^#; Zhao, Yao^#; Cai, Pengju; He, Zhesheng; Gao, Fuping^*; Zhang, Jinsong; Gao, Xueyun^*; Dose-Dependent Efficacy of Gold Clusters on Rheumatoid Arthritis Therapy,ACS Omega, 2019, 4(9): 14092-14099. (^#Equal contribution)

11. Li, Qiong^#;Yuan, Qing^#; Zhao, Mohan; Yao, Yawen; Gao, Liang; Liu, Ru; Wang, Yaling; Gong, Yong; Gao, Fuping^*; Gao, Xueyun^*; Au nanoclusters suppress chronic lymphocytic leukaemia cells by inhibiting thioredoxin reductase 1 to induce intracellular oxidative stress and apoptosis,Science Bulletin, 2017, 62(8): 537-545. (^#Equal contribution)

12.Yuan, Qing; Wang, Yaling; Zhao, Lina; Liu, Ru; Gao, Fuping; Gao, Liang^*; Gao, Xueyun^*; Peptide protected gold clusters: chemical synthesis and biomedical applications,Nanoscale, 2016, 8(24): 12095-12104.

13.Yuan, Qing; Han, Jing; Cong, Wenshu; Ge, Ying; Ma, Dandan; Dai, Zhaoxia; Li, Yaping^*; Bi, Xiaolin^*; Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with reduced myelosuppression toxicity,International Journal of Nanomedicine, 2014, 9: 4829-4846.

14. Gao, Fuping^#;Yuan, Qing^#; Gao, Liang; Cai, Pengju; Zhu, Huarui; Liu, Ru; Wang, Yaling; Wei, Yueteng; Huang, Guodong; Liang, Jian; Gao, Xueyun^*; Cytotoxicity and therapeutic effect of irinotecan combined with selenium nanoparticles,Biomaterials, 2014, 35(31): 8854-8866. (^#Equal contribution)

15. Kong, Ling^#;Yuan, Qing^#; Zhu, Huarui; Li, Ying; Guo, Quanyi; Wang, Qin; Bi, Xiaolin^*; Gao, Xueyun^*, The suppression of prostate LNCaP cancer cells growth by Selenium nanoparticles through Akt/Mdm2/AR controlled apoptosis,Biomaterials, 2011, 32(27), 6515-22. (^#Equal contribution)