基本信息

周志祥，博士，教授，博士生导师。北京工业大学生命科学与生物工程学院生物技术系，兼任中国环保部化学物质环境管理专家委员会委员、中国亚太医学生物免疫学会委员、中国光生物学专业委员会委员。1995年于北京师范大学获化学学士学位，2001年于中国科学院生物物理所获生物物理学博士学位，2004年至2007年间，于美国俄亥俄州立大学和哈佛大学麻省总医院完成博士后工作。2007年至今在北京工业大学从事教学与科研工作。2015年在美国宾州州立大学开展高级访问学者工作。科研方向主要是开展肿瘤发生的环境与病毒学机制研究，以及新型肿瘤早期诊断技术和肿瘤治疗技术的研发。作为主持人先后承担国家自然科学基金、环保部、科技部、教育部、中国科学院、及北京市优秀人才项目、北京市教委科技面上项目、北京市教委人才强校计划项目等课题项目。发表相关论文60余篇，其中SCI、EI收录40余篇，获国家发明专利4项，获软件著作权1部，获环保部科技奖二等奖2项，获云南省自然科学奖三等奖1项，出版专著2部等。

研究方向

机制：环境因素引起心肺疾病的机制研究；

诊断：环境因素监测、健康预警及疾病诊断技术；

治疗：抗肿瘤治疗性疫苗及生物纳米给药技术。

科研项目

1.环保部, SKLECRA2015OFP13,我国典型城市空气PM2.5对人肺上皮细胞的毒性效应及效应标志物研究, 2015/06-2017/06,主持。

2.中国科学院，2005DP173065-2013-06, PM2.5的毒理基因组学研究,2014/01-2015/12,主持。

3.环保部，201109037,化学品危害诊断、分类、暴露预测及名录研究之毒理学数学模型研究, 2011/01-2013/12,主持。

4.北京市教委，JC015001201102,基于HPV16 E6E7基因的宫颈癌治疗性疫苗研制, 2010/01-2012/12,主持。

5.北京市教委, 01500054313502, miR34影响肿瘤治疗敏感性的机制研究, 2011/01-2013/12,主持。

6.科技部国际合作项目，2011DFG33200,手足口病预防性基因工程重组疫苗研发项目, 2012/03-2015/02,参与。

7.教育部留学回国人员启动基金，32015001201001 ,竹红菌素类光敏剂光诱导癌细胞凋亡的线粒体机制研究, 2010/04-2013/12,主持。

8.北京市组织部优秀人才项目，Q0015001200801,定位在线粒体的竹红菌素类光敏剂光诱导癌细胞凋亡的机制研究, 2009/01-2010/12,主持。

9.环保部“国家环境基准管理”,2017-09-2020-09，主持

10.国家自然科学基金，大气PM2.5诱导肺气血屏障损伤中自噬效应及其作用研究，2018-1-2020-12，主持

主要学术论文

1. Liu W, An X, Wang J, Zhang X, Tan J, ZhouZhixiang*, Zeng Y. A novel peptide shows excellent anti-HIV-1 potency as a gp41fusion inhibitor. Bioorg Med Chem Lett. 2018 Mar 1;28(5):910-914. doi:10.1016/j.bmcl.2018.01.061. IF2.454

2. Yu Y, Li L, Li H, Yu X, ZhangY, Wang Q,ZhouZhixiang*, Gao D, Ye H, Lin B, Ma R. In vivoassessment of dermal adhesion, penetration, and bioavailability oftetrabromobisphenol A. Environ Pollut. 2017 Sep;228:305-310. doi:10.1016/j.envpol.2017.05.008. Epub 2017 May 25.IF 5.099二区

3. SH3GLB2/endophilin B2regulates lung homeostasis and recovery from severe influenza A virusinfection. Fino KK, Yang L, Silveyra P, Hu S, Umstead TM, DiAngelo S, HalsteadES, Cooper TK, Abraham T, Takahashi Y, Zhou Z, Wang HG, Chroneos ZC. Sci Rep.2017 Aug 4;7(1):7262. doi: 10.1038/s41598-017-07724-5.IF 4.259

4. Zhou Zhixiang*,Tong Shao, Mengnan Qin, Xiaoyan Miao, Yunjiang Yu. The effects of autophagy onvascular endothelial cells induced by airborne PM2.5 Journal of EnvironmentalSciences, In press, corrected proof, Available online 19 May 2017

5. Serfass JM, Takahashi Y, ZhouZ¹, Kawasawa YI, Liu Y, Tsotakos N, Young MM, Tang Z, Yang L,Atkinson JM, Chroneos ZC, Wang HG. Endophilin B2 facilitates endosomematuration in response to growth factor stimulation, autophagy induction, andinfluenza A virus infection. J Biol Chem. 2017 Jun 16;292(24):10097-10111. doi:10.1074/jbc.M117.792747.IF 4.125二区

6. Deng X, Yin Z, Lu J, Xia Y,Shao L, Hu Q, Zhou Z, Zhang F, Zhou S, Wu Y, Sheng W, Zeng Y. Two-StepAssembling of Near-Infrared "OFF-ON" Fluorescent Nanohybrids forSynchronous Tumor Imaging and MicroRNA Modulation-Based Therapy. ACS Appl MaterInterfaces. 2017 Feb 1;9(4):3294-3305. doi: 10.1021/acsami.6b11438. IF 7.504一区

7. Zhang B¹, Wei P¹,ZhouZhixiang¹, Wei T. Interactions of graphenewith mammalian cells: Molecular mechanisms and biomedical insights. Adv DrugDeliv Rev. 2016; 105(Pt B):145-162. doi: 10.1016/j.addr.2016.08.009. IF 11.764一区

8. Deng X, Yin Z,ZhouZhixiang¹, Wang Y, Zhang F, Hu Q, Yang Y,Lu J, Wu Y, Sheng W, Zeng Y. Carboxymethyl Dextran-StabilizedPolyethylenimine-Poly (epsilon-caprolactone) Nanoparticles-Mediated Modulationof MicroRNA-34a Expression via Small-Molecule Modulator for HepatocellularCarcinoma Therapy. ACS Appl Mater Interfaces. 2016; 8(27):17068-79. doi:10.1021/acsami.6b03122. IF. 7.504

9. Zhou Zhixiang*, Yanghua Liu,Fengkui Duan, Mengnan Qin, Fengchang Wu, Wang Sheng, Lixin Yang, Jianguo Liu,Kebin He. Transcriptomic Analyses of the Biological Effects of Airborne PM2.5Exposure on Human Bronchial Epithelial Cells. PLOS ONE，2015, 10(9):e0138267. IF 3.702

10. Yanghua Liu,ZhouZhixiang*, Xialong Zhang, Handong Li. Development ofQSAR model for predicting the mutagenicity of Aromatic compounds. Chinese J.Struct. Chem. 2015, 34(3): 224-234. IF 0.507

11. Zhou Zhixiang*,Dan Li, Shanshan Guan, Chen Zhao, Zelin Li, Yi Zeng. Immunotherapeutic Effectsof Dendritic Cells Pulsed with a Coden-optimized HPV 16 E6 and E7 Fusion Genein Vivo and in Vitro. Asian Pac J Cancer Prev. 2015,16(9):3843-7. IF 2.514

12. ZhouZhixiang*, Yanghua Liu, Mengnan Qin, Wang Sheng,Xiaoli Wang, Zelin Li, Rugang ZhongDepletion of PKM2 leads to impaired glycolysis andcell death in 2-demethoxy-2, 3-ethylenediamino hypocrellin B-photoinduced A549cells,J Photochem Photobiol B. 2014, 134(5): 1–8. IF 3.13

13. Xiaolong Zhang，ZhouZhixiang*, Yanghua Liu, Handong Li，Jiantao Wang. Predicting Acute Toxicity of Aromatic Amines byLinear and Nonlinear Regression Methods. Chinese J. Struct. Chem. 2014,33(2):244-252. IF 0.507

14. Zhou Zhixiang*,Zhao C, Li Q, Zeng Y. A novel mutant of human papillomavirus type 18 E6E7fusion gene and its transforming activity. Asian Pac J Cancer Prev. 2014,15(17):7395-9. IF 2.514

15. Deng X, Cao M, Zhang J, Hu K,Yin Z,ZhouZhixiang¹, Xiao X, Yang Y, Sheng W, Wu Y,Zeng Y.Hyaluronic acid-chitosan nanoparticles for co-delivery ofMiR-34a and doxorubicin in therapy against triple negative breast cancer.Biomaterials. 2014, 35(14): 4333-4344. IF8.402.一区

16. Zhang X，Zhou Zhixiang*,Liu Y, Fan X, Wang J, Li H, QSTR studies on acute toxicity and mutagenicity ofhalogenated benzenes compounds，AsianJournal f Chemistry, 2014, 26(9): 2707-2710.IF 0.35

17. ZhouZhixiang*, Mengnan Qin, Yanghua Liu, Xiaolong Zhang,Handong Li，QuantitativeStructure-Toxicity Relationship for Predicting Acute Toxicity of Phenols，doi:10.2991/bst-16.2016.2

18. ZhouZhixiang*, Li Q, Liu W, Zhang L, Wang X, Ma H, ShengW, Li Z, Zeng Y, Zhong R. Photo-killing mechanism of2-demethoxy-2,3-ethylenediamino hypocrellin B (EDAHB) to HeLa cells. JPhotochem Photobiol B. 2012, 117: 47-54.IF 3.13

19. ZhouZhixiang*, Zhao C, Liu W, Li Q, Zhang L, Sheng W, LiZ, Zeng Y, Zhong R.Involvement of the Mitochondria-Caspase Pathway in HeLa CellDeath Induced by 2-Ethanolamino-2-Demethoxy-17-Ethanolimino-Hypocrellin B(EAHB)-Mediated Photodynamic Therapy. Int J Toxicol. 2012, 31(5): 483-92. IF1.371

20. ZhouZhixiang*, Zhang LN, Liu HM et al.Photocytotoxicity ofHypocrellin B (HB) was Enhanced by Liposomalization in Vitro. Int J Toxicol.2011, 30(2): 174-180.IF 1.371

21. Deng X, Wang Y, Zhang F, Yin Z, Hu Q, Xiao X, Zhou Z, Wu Y, ShengW, Zeng Y. Acidic pH-induced charge-reversal nanoparticles for acceleratedendosomal escape and enhanced microRNA modulation in cancer cells. Chem Commun(Camb). 2016;52(15):3243-6. IF 6.319一区

22. Shihua Wang, Minjun Cao,Xiongwei Deng, Xiangqian Xiao, Zhaoxia Yin, Qin Hu, Zhixiang Zhou, Fang Zhang,Ruirui Zhang, Yan Wu, Wang Sheng, Yi Zeng. Degradable hyaluronic acid/protaminesulfate interpolyelectrolyte complexes as miRNA-delivery nanocapsules fortriple-negative breast cancer therapy. Adv Healthc Mater. 2015, 4(2): 281-90.IF 5.11.一区

23. Zhang F, Yang Z, Cao M, Xu Y,Li J, Chen X, Gao Z, Xin J, Zhou S, Zhou Z, Yang Y, Sheng W, Zeng Y.MiR-203 suppresses tumor growth andinvasion and down-regulates MiR-21 expression through repressing Ran inesophageal cancer.Cancer Lett.2014, 342(1): 121-129. IF 6.373二区

24. Yanghua Liu,ZhouZhixiang*, Xialong Zhang, Handong Li. QSTR Study forthe Carcinogenicity of Alkylbenzenes. Applied Mechanics and Materials. 2014,665: 567-570.（EI）