孙国辉  

 

 

非官方人士.jpg

 


一、基本情况

孙国辉,男,1989年8月生,安徽合肥人,中共党员,博士,副教授,硕士生导师。现任北京工业大学环境与生命学部副主任,环境与生命学部教师。

2017年毕业于北京工业大学生命学院,获生物医学工程专业博士学位。兼任中国药学会高级会员、美国化学会会员、中国化学会会员、中国药理学会会员和中国生物医学工程学会会员等学术职务。

主持和参与的科研项目包括国家自然科学基金、北京市自然科学基金、中国博士后科学基金和北京市博士后科学基金等。目前以第一作者或通讯作者发表SCI论文19篇,申请及获批国家发明专利3项。担任多种SCI期刊审稿人。

20192020MDPI出版社杰出审稿人代表奖。

担任SCI期刊Frontiers in Bioscience-Landmark编委(IF4.00920212~至今)和专刊客座编辑Guest Editor(专刊:Recent advances in cancer research and environmental toxicology);

担任中文核心期刊《化学试剂》第一届青年编委(2021.09~2023.09

二、研究方向

分子毒理学与癌症防治。围绕癌症防治工作,重点开展DNA抗癌烷化剂的作用机理及耐药性调控研究,以及环境污染物的毒性、突变性及致癌性机理和构效关系研究。具体研究工作有以下几个方面:

1. DNA抗癌烷化剂的作用机理研究:寻找肿瘤化疗的生物标志物,设计高活性抗癌烷化剂。

2. 化疗药物的耐药性调控研究:研发高效低毒的化疗增敏剂,提高化疗药物抗肿瘤效果。

3. 环境与分子毒理学:主要研究环境污染物的构效关系,对人体健康和环境风险评估具有重要的指导意义。

三、主持和参与的课题

1. 基于嘌呤和嘧啶核心骨架的肿瘤靶向性MGMT抑制剂的设计、合成与生物活性评价,国家自然科学基金(2021.01-2023.12)No.82003599,主持。

2. 糖酵解抑制剂对氯乙基亚硝基脲耐药性的调控机制研究,北京市教委科技计划一般项目(2021.01-2023.12)No. KM202110005005,主持。

3. 3-溴丙酮酸与氯乙基亚硝基脲联合用药的抗肿瘤活性及其作用机制研究,北京市自然科学基金青年基金(2018.01-2019.12)No.7184192,主持。

4. 能量代谢抑制剂 3-溴丙酮酸联合亚硝基脲的抗癌活性研究,中国博士后基金面上项目(2017.12-2019.08)No. 2017M620567,主持。

5. 糖酵解抑制剂对氯乙基亚硝基脲耐药性的调控作用及其机制研究,北京市博士后基金(2018.07-2019.08)No. 2018-ZZ-022,主持。

6. 3-溴丙酮酸逆转神经胶质瘤亚硝基脲耐药性的作用机理研究,朝阳区博士后基金(2018.12-2019.08)No. 2018ZZ-01-25,主持。

7. 北京工业大学博士科研启动基金,2020.01-2020.12,主持。

8. 低氧激活联合亚硝基脲的作用机理及抗癌活性研究,国家自然科学基金面上项目(2018.01-2021.12)No. 21778011,参与。

四、代表性研究论文和专利

[1] Sun, G.H.*; Zhang, Y.F.; Pei, L.Y.; Lou, Y.Q.; Mu, Y.; Yun, J.Y.; Li, F.F.; Wang, Y.C.; Hao, Z.Q.; Xi, S.; Li, C.; Chen, C.H.; Zhao, L.J.*; Zhang, N.; Zhong, R.G.; Peng, Y.Z. Chemometric QSAR modeling of acute oral toxicity of Polycyclic Aromatic Hydrocarbons (PAHs) to rat using simple 2D descriptors and interspecies toxicity modeling with mouse. Ecotoxicology and Environmental Safety. 2021, 222, 112525. (IF: 6.291, JCR 1, Top期刊) (第一/通讯作者)

[2] Huang, T.; Sun, G.H.*; Zhao, L.J.; Zhang, N.; Zhong, R.G.; Peng, Y.Z. Quantitative Structure-Activity Relationship (QSAR) studies on the toxic effects of nitroaromatic compounds (NACs): A systematic review. International Journal of Molecular Sciences, 2021, 22, 8557. (IF:5.923, JCR 1区,TOP期刊) (通讯作者)

[3] Zhang, C.; Hong, L.; Ma, N.*; Sun, G. H.* Logic analysis of how the emergency management legal system used to deal with public emerging infectious diseases under balancing of competing interests—the case of COVID-19. Healthcare 2021, 9, 857. (IF: 2.645, JCR 2) (通讯作者)

[4] Ma, N.; Ma, S.; Li, S. J.; Ma, S.*; Pan, X. Z.; Sun, G. H.* The study of spatial safety and social psychological health features of deaf children and children with an intellectual disability in the public school environment based on the visual access and exposure (VAE) model. International Journal of Environmental Research and Public Health, 2021, 18(8), 4322. (IF: 3.39, JCR 1) (通讯作者)

[5] Hao, Y. X.; Sun, G. H.*; Fan, T. J.; Tang, X. Y.; Zhang J.; Liu, Y. D.; Zhang, N.; Zhao, L. J.; Zhong, R. G.; Peng, Y. Z. In vivo toxicity of nitroaromatic compounds to rats: QSTR modelling and interspecies toxicity relationship with mouse. Journal of Hazardous Materials, 2020, 399, 122981. (IF: 10.588, JCR 1, Top期刊) (通讯作者)

[6] Huang, Y. X.; Sun, G. H.*; Sun, X. D.; Li, F. F.; Zhao, L. J.; Zhong, R. G.; Peng, Y. Z. The potential of lonidamine in combination with chemotherapy and physical therapy in cancer treatment. Cancers, 2020, 12, 3332. (IF:6.639, JCR 1) (通讯作者)

[7] Sun, X. D.; Sun, G. H.*; Huang, Y. X.; Hao Y. X.; Tang, X. Y.; Zhang, N.; Zhao, L. J.; Zhong, R. G.; Peng, Y. Z. 3-Bromopyruvate regulates the status of glycolysis and BCNU sensitivity in human hepatocellular carcinoma cells. Biochemical Pharmacology, 2020, 177, 113988. (IF: 5.858, JCR 1, Top期刊) (通讯作者)

[8] Sun, X. D.; Sun, G. H.*; Huang, Y. X.; Zhang, S. F.; Tang, X. Y.; Zhang, N.; Zhao, L. J.; Zhong, R. G.; Peng, Y. Z. Glycolytic inhibition by 3-bromopyruvate increases the cytotoxic effects of chloroethylnitrosoureas to human glioma cells and the DNA interstrand cross-links formation. Toxicology, 2020, 435, 152413. (IF: 4.221, JCR 2) (通讯作者)

[9] Hao, Y. X.; Sun, G. H.*; Fan, T. J.; Sun, X. D.; Liu, Y. D.; Zhang, N.; Zhao, L. J.; Zhong, R. G.; Peng, Y. Z. Prediction on the mutagenicity of nitroaromatic compounds using quantum chemistry descriptors based QSAR and machine learning derived classification methods. Ecotoxicology and Environmental Safety, 2019, 186, 109822. (IF: 6.291, JCR 1, Top期刊) (通讯作者)

[10] Fan T. J.; Sun, G. H.*; Sun X. D.; Zhao, L. J.; Zhong, R. G.; Peng Y. Z. Tumor energy metabolism and potential of 3-bromopyruvate as an inhibitor of aerobic glycolysis: implications in tumor treatment. Cancers, 2019, 11, 317. (IF:6.639, JCR 1区,Editor’s Choice) (通讯作者)

[11] Sun, G. H.*; Fan, T. J.; Sun, X. D.; Hao, Y. X.; Cui, X.; Zhao, L. J.*; Ren, T.; Zhou, Y.; Zhong, R. G.; Peng, Y. Z. In silico prediction of O6-methylguanine-DNA methyltransferase inhibitory potency of base analogs with QSAR and machine learning methods. Molecules, 2018, 23, 2892. (IF:4.411 JCR 2) (Feature Paper) (第一/通讯作者)

[12] Sun, G. H.; Zhao, L. J.*; Zhong, R. G.; Peng, Y. Z. The specific role of O6-methylguanine-DNA methyltransferase inhibitors in cancer chemotherapy. Future Medicinal Chemistry, 2018, 10, 1971-1996. (IF:3.808, JCR 2) (第一作者)

[13] Sun, G. H.; Fan, T. J.; Zhao, L. J.*; Zhou, Y.; Zhong, R. G. The potential of combi-molecules with DNA-damaging function as anticancer agents. Future Medicinal Chemistry, 2017, 9, 403-435. (IF:3.808, JCR 2) (第一作者)

[14] Sun, G. H.; Zhang, N.; Zhao, L. J.*; Fan, T. J.; Zhang, S. F.; Zhong, R. G. Synthesis and antitumor activity evaluation of a novel combi-nitrosourea prodrug: Designed to release a DNA cross-linking agent and an inhibitor of O6-alkylguanine-DNA alkyltransferase. Bioorganic & Medicinal Chemistry, 2016, 24, 2097-2107. (IF:3.641, JCR 2) (第一作者)

[15] Sun, G. H.; Zhao, L. J.*; Fan, T. J.; Ren, T.; Zhong, R. G. Measurement of O6-alkylguanine-DNA alkyltransferase activity in tumour cells using stable isotope dilution HPLC-ESI-MS/MS. Journal of Chromatography B, 2016, 1033, 138-146. (IF:3.205, JCR 2) (第一作者)

[16] Sun, G. H.; Fan, T. J.; Zhang, N.; Ren, T.; Zhao, L. J.*; Zhong, R. G. Identification of the structural features of guanine derivatives as MGMT inhibitors using 3D-QSAR modeling combined with molecular docking. Molecules, 2016, 21, 823. (IF:4.411, JCR 2) (第一作者)

[17] Sun, G. H.; Zhao, L. J.*; Zhong, R. G. The induction and repair of DNA interstrand crosslinks and implications in cancer chemotherapy. Anti-Cancer Agents in Medicinal Chemistry, 2016, 16, 221-246. (IF:2.505) (第一作者, JCR 3)

[18] Sun, G. H.; Zhao, L. J.*; Fan, T. J.; Li, S. S.; Zhong, R. G. Investigations on the effect of O6-benzylguanine on the formation of dG-dC interstrand cross-links induced by chloroethylnitrosoureas in human glioma cells using stable isotope dilution high-performance liquid chromatography electrospray ionization tandem mass spectrometry. Chemical Research in Toxicology, 2014, 27, 1253-1262. (IF:3.739, JCR 2) (第一作者)

[19] Fan, T. J.†; Sun, G. H.†; Zhao, L. J.*; Cui, X.; Zhong, R. G. QSAR and classification study on prediction of acute oral toxicity of N-nitroso compounds. International Journal of Molecular Sciences, 2018, 19, 3015. (Co-first author, IF:5.923, JCR 1区,TOP期刊)

[20] 孙国辉,肖伟男,孙晓东,范腾蛟,赵丽娇,钟儒刚,彭永臻. 一种低氧靶向肿瘤细胞DNA修复酶MGMT抑制剂及其制备方法与应用. 国家发明专利(已授权). 专利号: ZL201811634039.3

[21] 孙国辉,黄雅馨,郝兆骐,李辰,王雅琛,锡莎,孙晓东,张娜,赵丽娇,钟儒刚. 硝基苯取代的O6-3-氨甲基苄基鸟嘌呤及其制备方法与应用. 国家发明专利. 申请号: CN202010184141.9.

[22] 赵丽娇, 孙国辉, 钟儒刚. 一种新型的β-氯乙基亚硝基脲类化合物及其合成方法和用途. 国家发明专利(已授权). 专利号: ZL201410231997.1

[23] 陈硕,李非凡,孙国辉*,赵丽娇,钟儒刚. QSAR建模及其在抗病毒药物设计与筛选中的研究进展. 化学试剂. 2021, 43(7), 895~905. (通讯作者)

五、招生方向

0710 生物学:03药物化学与化学生物学、04环境生物学与食品安全

0854:电子信息/生物医学工程(专业学位)

欢迎对我的研究方向感兴趣,踏实乐观、能吃苦、有团队精神和责任意识的新时代青年学生加入!!!

六、联系方式

北京市朝阳区平乐园100

北京工业大学环境与生命学部 (生命楼B214)

邮政编码:100124

E-mail: sunguohui@bjut.edu.cn

北京工业大学研究生招生办公室 地址:北京市朝阳区平乐园100号 邮政编码:100124 联系电话:010-67392533