赵洪武  



赵洪武.jpg

赵洪武 副研究员 硕士生导师

联系电话:86-10-67396211

通讯地址:北京市朝阳区平乐园100号,

北京工业大学环境与生命学部,化学与生物系,生命楼B624研究室

电子邮箱:hwzhao@bjut.edu.cn 

一、教育背景

1997年--2000年,北京大学,化学与分子工程学院,博士

1992年--1995年,东北师范大学,化学系,硕士

1988年--1992年,东北师范大学,化学系,本科

二、工作经历

2007年--现在,北京工业大学,副研究员

2006年--2007年,开拓者制药公司(美国EliLilly),研发总监

2004年--2006年,美国普渡大学,药学院,博士后

2001年--2004年,美国弗吉尼亚理工大学,化学系,博士后

2000年--2001年,香港大学,化学系,博士后

1995年--1997年,大连理工大学,石油化工学院,讲师

三、研究方向

1.靶向性抗肿瘤药物的设计与合成

2.手性螺(稠)杂环类药性分子骨架的设计与合成

3.不对称有机催化和金属催化有机合成方法学的研究

4.手性识别的研究

四、课程教学

有机化学(主讲)、生物材料(主讲)、药物合成(主讲/双语)、药物化学(双语/主讲)、生物医学工程概论、药物合成技术

五、奖项荣誉

1.北京工业大学优秀硕士学位论文指导教师(11次)

2.北京工业大学绩效考核优秀奖(4次)

3.北京工业大学“双带头人”教师党支部书记示范工作室(2019年)

4.生命科学与生物工程学院(原)优秀共产党员(2017年)

5.北京市人才强教深化计划中青年骨干人才(2010年)

六、主要科研项目

作为项目负责人,主持了国家科技重大专项1项、北京市自然科学基金3项、北京市教委项目2项、北京市人才强教深化计划中青 年骨干人才项目1项、企业委托项目2项、校级项目2项。作为研究骨干,参与了国家重点基础研究发展计划2项、国家科技重大专项2项、北京市教委项目1项。

1.靶向FBPase的抗糖尿病新药研究病,国家重大专项,主持,2018/01-2020/12

2.新型手性螺环巴比妥的设计、合成和抗肿瘤活性评价药研究,北京市自然科学基金,主持,2017/01-2019/12

3.新型双功能小分子催化剂的设计、合成和不对称催化反应的研究,北京市自然科学基金,主持,2012/01-2014/12

4.新型桥连联苯化合物的设计、合成与抗肿瘤活性研究,北京市自然科学基金,主持,2010/01-2012/12

5.新型(-)-Rhazinilam桥连联芳基化合物的设计、立体选择性合成和构效关系研究,北京市人才强教计划,主持,2010/01-2013/12

6.新型秋水仙碱B环类似物的设计、合成和构效关系研究,北京市教委项目,主持,2009/01-2011/12

7.芳基二氢吡啶酮化合物的合成,企事业委托项目,主持,2010/01-2011/12

七、主要论文论著

J.Am.Che.Soc.,Org.Lett.,Chem.Commun.Adv.Synth.&Catal.,J.Org.Chem.SCI收录的国际著名学术刊物上发表科研论文50余篇;申请国家发明专利10余项。

(一)代表性SCI论文

1.Xiao-ZuFan,Hui-HuiWu,ZheTang,HengZhang,Lu-YuCai,Xiao-FanBi,Hong-WuZhao,*Formal[3+2]CycloadditionBetweeninsituFormed1,4-Benzodiazepin-2-One-BasedAzomethineYlideswithAzodicarboxylicAcidDerivatives:DiastereoselectiveSynthesisofSpiro-1,4-Benzodiazepin-2-Ones,Adv.Synth.&Catal.,2021,363,1379-1389.

2.Hui-HuiWu,Xiao-ZuFan,ZheTang,HengZhang,Lu-YuCai,Xiao-FanBi,Hong-WuZhao,*Palladium/LigandComplexCatalyzedFormal[5+6]CycloadditionofVinylethyleneCarbonateswithIsatoicAnhydridesforSynthesisofMedium-SizedN,O-ContainingHeterocycles,Org.Lett.,2021,23,2802−2806.

3.H.W.Zhao,*L.R.Wang,W.Q.Ding,etal.Formal[5+3]CycloadditionbetweenIsatin-Basedα-(Trifluoromethyl)imineYlidesandVinyloxiranes:DiastereoselectiveAccesstoMedium-Heterocycle-FusedSpirooxindoles,Synlett,2021,32(01),57-62.

4.Jia-MingGuo,Xiao-ZuFan,Hui-HuiWu,ZheTang,Xiao-FanBi,HengZhang,Lu-YuCai,Hong-WuZhao,*andQi-DiZhong.AsymmetricSynthesisofSpiropyrazolonesviaChiralPd(0)/LigandComplex-CatalyzedFormal[4+2]CycloadditionofVinylBenzoxazinanoneswithAlkylidenePyrazolones,J.Org.Chem.2021,86,1712-1720.

5.H.W.Zhao,*W.Q.Ding,L.R.Wang,etalFormal[5+2]CycloadditionofVinyloxiraneswithOxazol-5-(4H)-ones:AFacileApproachforConstructionofSeven-MemberedLactones,Eur.J.Org.Chem.,2020,2020(34),5557-5562,

6.H.W.Zhao,*J.M.Guo,L.R.Wang,etal.Diastereoselectiveformal[3+3]cycloadditionofisatin-basedalpha-(trifluoromethyl)imineswithN,N'-dialkyloxyureas,Org.Chem.Front.,2019,6,3891-3895,

7.H.W.Zhao,*W.Q.Ding,J.M.Guo,etal.Formal[4+2]CycloadditionofVinylBenzoxazinoneswithOxazol-5-(4H)-onesforDiastereoselectiveConstructionof3,4-DisubstitutedDihydro-2(1H)-Quinolinones,Adv.Synth.&Catal.,2019,361(17),4111-4116,

8.H.W.Zhao,*L.R.Wang,J.M.Guo,etal.Formal[5+3]CycloadditionofVinylethyleneCarbonateswithIsatin-Basedalpha-(Trifluoromethyl)iminesforDiastereoselectiveSynthesisofMedium-Heterocycle-FusedSpirooxindoles,Adv.Synth.&Catal.,2019,361(20),4761-4771,

9.Hong-WuZhao,*JuanDu,Jia-MingGuo,Ning-NingFeng,Li-RuWang,Wan-QiuDingandXiu-QingSongFormal[5+2]cycloadditionofvinylethylenecarbonatestooxazol-5-(4H)-onesforthesynthesisof3,4-dihydrooxepin-2(7H)-ones,Chem.Commun.,2018,54,9178–9181,

10.Hong-WuZhao,*Ning-NingFeng,Jia-MingGuo,JuanDu,Wan-QiuDing,Li-RuWang,andXiu-QingSongDiastereoselectiveandEnantioselectiveSynthesisofBarbiturate-FusedSpirotetrahydroquinolinesviaChiralPalladium(0)/LigandComplexCatalyzed[4+2]CycloadditionofVinylBenzoxazinanoneswithBarbiturate-BasedOlefinsJ.Org.Chem.2018,83,9291-9299,

11.Hong-WuZhao,*Yue-YangLiu,Yu-DiZhao,Ning-NingFeng,JuanDu,Xiu-QingSong,Hai-LiangPang,Xiao-QinChen,Base-catalyzed[3+2]CycloadditionofDiazooxindoleswithOxazol-5-(4H)-onesforSynthesisofNovel3-(1H-1,2,4-triazol-1-yl)indolin-2-ones,Eur.J.Org.Chem.,20182017341-346,

12.Hong-WuZhao,*Yu-DiZhao,Yue-YangLiu,Li-JiaoZhao,Xiu-QingSong,Xiao-QinChen,Hai-LiangPang,JuanDuandNing-NingFeng,1,3-Dipolar[3+3]cycloadditionofahalohydroxamate-basedazaoxyallylcationswithhydrazonoylchloride-derivednitrileimines,RSCAdv.,2017,7,55106–55109,

13.Hong-WuZhao,*Xiao-QinChen,Yu-DiZhao,Yue-YangLiu,Hai-LiangPang,Xiu-QingSong,TingTian,BoLi,ZhaoYang,JuanDu,Ning-NingFeng,[3+2]CycloadditionBetween3-IsothiocyanatoOxindolesandNitrosoCompounds,Eur.J.Org.Chem.,201720173139-3144,

14.Hong-WuZhao,*Yu-DiZhao,Yue-YangLiu,JuanDu,Hai-LiangPang,Xiao-QinChen,Xiu-QingSong,Ning-NingFeng,Base-promoted[3+2]CycloadditionofinsituformedAzaoxyallylCationswithIsothiocyanides,Eur.J.Org.Chem.,20172017,3466–3472,

15.Hong-WuZhao,*Hai-LiangPang,Yu-DiZhao,Yue-YangLiu,Li-JiaoZhao,Xiao-QinChen,Xiu-QingSong,Ning-NingFengandJuanDuConstructionof2,3,4,5-tetrahydro-1,2,4-triazinesvia[4+2]cycloadditionofα-halogenohydrazonestoiminesRSCAdv.,2017,7,9264-9271,

16.Hong-WuZhao,*Yu-DiZhao,Yue-YangLiu,Li-JiaoZhao,*Ning-NingFeng,Hai-LiangPang,Xiao-QinChen,Xiu-QingSong,JuanDuAfacileaccesstonovel1,2,4-oxadiazinan-5-onesvia[3+3]cycloadditionofinsitugeneratedazaoxyallylcationswithnitronesRSCAdv.,20177,12916-12922,

17.Hong-WuZhao,*Yue-YangLiu,Yu-DiZhao,Hai-LiangPang,Xiao-QinChen,Xiu-QingSong,TingTian,BoLi,ZhaoYang,JuanDu,Ning-NingFeng[3+2]CycloadditionofOxazol-5-(4H)-oneswithNitronesforDiastereoselectiveSynthesisofIsoxazolidin-5-ones,Org.Lett.,20171926-29,

18.Hong-WuZhao,*Hai-LiangPang,TingTian,BoLi,Xiao-QinChen,Xiu-QingSong,WeiMeng,ZhaoYang,Yue-YangLiu,Yu-DiZhao,Constructionof2,3,4,7-tetrahydro-1,2,4,5-oxatriazepinevia[4+3]cycloadditionofα-halogenohydrazoneswithnitrones,Adv.Synth.&Catal.2016,358,1826–1832,

19.Hong-WuZhao,*BoLi,Hai-LiangPang,TingTian,Xiao-QinChen,Xiu-QingSong,WeiMeng,ZhaoYang,Yu-DiZhao,Yue-YangLiuDiastereoselective1,3-dipolarcycloadditionsofN,N’-cyclicazomethineimineswithiminooxindolesforaccesstooxindole-spiro-N,N-bicyclicheterocycles,Org.Lett.201618848-851,

20.Hong-WuZhao,*Hai-LiangPang,BoLi,TingTian,Xiao-QinChen,Xiu-QingSong,WeiMeng,ZhaoYang,Yue-YangLiu,Yu-DiZhao,DirectAccesstoNon-Aromatic1,2,3,6-Tetrahydro-1,2,3,4-Tetrazinesvia[4+2]Cycloadditionofα-HalogenoHydrazoneswithAzodicarboxylicAcidDerivatives,RSCAdv.2016,6,25562-25567,

21.Hong-WuZhao,*TingTian,Hai-LiangPang,BoLi,ZhaoYang,WeiMeng,Xiu-QingSong,Xiao-QinChen,Organocatalytic[3+2]CycloadditionofBarbiturate-BasedOlefinswith3-IsothiocyanatoOxindoles:HighlyDiastereoselectiveandEnantioselectiveSynthesisofDispirobarbituratesAdv.Synth.&Catal.2016,358,2619-2630,

22.Hong-WuZhao,*BoLi,TingTian,Xiu-QingSong,Hai-LiangPang,Xiao-QinChen,ZhaoYang,WeiMeng,Facileconstructionofnovelimidazolidine-spirooxindolesviadiastereoselectivecycloadditionofN-acylhydrazine-derivedimineswith3-isothiocyanatooxindoles,RSCAdv.2016,6,27690-27695,

23.Hong-WuZhao,*Xiao-QinChen,Hai-LiangPang,TingTian,BoLi,Xiu-QingSong,WeiMeng,ZhaoYang,Yu-DiZhao,Yue-YangLiu,DiastereoselectivesynthesisofhighlyfunctionalizedpolycyclicbenzosultamsviatandemcyclisationsofcyclicN-sulfonylimineswithinsitugeneratedHuisgen1,4-dipoles,RSCAdv.20166,61732-61739,

24.Zhao,H.-W.;*Tian,T.;Li,B.;Yang,Z.;Pang,H.-L.;Meng,W.;Song,X.-Q.;Chen,X.-Q.,DiastereoselectiveSynthesisofDispirobarbituratesthroughEt3N-Catalyzed[3+2]CycloadditionofBarbiturate-BasedOlefinswith3-IsothiocyanatoOxindoles.J.Org.Chem.2015,80,10380-10385,

25.Zhao,H.-W.;*Chen,X.-Q.;Yang,Z.;Tian,T.;Li,B.;Meng,W.;Song,X.-Q.;Pang,H.-L.,Highlydiastereoselectivesynthesisofimidazolidine-dispirooxindolesviathree-component[3+2]cycloadditionsofisatins,2-(aminomethyl)pyridineandisatin-basedimines.RSCAdv.2015,5,103116-103122,

26.Zhao,H.-W.;*Yang,Z.;Meng,W.;Tian,T.;Li,B.;Song,X.-Q.;Chen,X.-Q.;Pang,H.-L.,Diastereo-andEnantioselectiveSynthesisofChiralPyrrolidine-FusedSpirooxindolesviaOrganocatalytic[3+2]1,3-DipolarCycloadditionofAzomethineYlideswithMaleimides.Adv.Synth.&Catal.2015,357,2492-2502,

27.Zhao,H.-W.;*Li,B.;Tian,T.;Meng,W.;Yang,Z.;Song,X.-Q.;Chen,X.-Q.;Pang,H.-L.,HighlyEnantioselectiveSynthesisofChiralPyranonaphthoquinone-FusedSpirooxindolesthroughOrganocatalyticThree-ComponentCascadeReactions.Eur.J.Org.Chem.2015,2015,3320-3326.

28.PaulR.Carlier,*HongwuZhao,StephanieL.MacQuarrie-Hunter,JosephC.DeGuzman,andDannyC.Hsu,EnantioselectiveSynthesisofDiverselySubstitutedQuaternary1,4-Benzodiazepin-2-onesand1,4-Benzodiazepine-2,5-diones.J.Am.Soc.Chem.2006,128,15215-15220.

29.PaulR.Carlier,*HongwuZhao,JoeDeGuzman,andPoloC.-H.Lam.EnantioselectiveSynthesisof“Quaternary”1,4-Benzodiazepin-2-oneScaffoldsviaMemoryofChirality.J.Am.Chem.Soc.2003,125,11482-11483.

30.HongwuZhaoandWentingHua.*SynthesisandCharacterizationofPyridine-BasedPolyamido-PolyesterOpticallyActiveMacrocyclesandEnantiomericRecognitionford-andl-AminoAcidMethylEsterHydrochloride.J.Org.Chem.2000,65,2933-2938.

(二)代表性国家发明专利

1.一种3,4-二氢氧基-2(7H)-酮及制备方法,专利号:ZL201810449534.0,第一发明人.

2.一种八元氮氧杂环螺吲哚酮化合物及制备方法,专利号:ZL201811028971.1,第一发明人.

3.一种手性3,4-二氢-2(1H)-喹啉酮类化合物及制备方法,专利号:ZL201811574684.0,第一发明人.

4.一种手性巴比妥螺四氢喹啉类化合物及制备方法,专利号:ZL201810449570.7,第一发明人.

5.一种手性1,4-苯并二氮䓬-2-酮螺杂环化合物及制备方法,申请号:202011442438.7(实申阶段),第一发明人.

6.一种氮杂中环内酯化合物及制备方法,申请号:202011441268.0(实申阶段),第一发明人.

7.一种手性螺环吡唑啉酮化合物及制备方法,申请号:202110058934.0(实申阶段),第一发明人.

8.一种手性噁二嗪杂环稠合1,4-苯并二氮䓬-2-酮类化合物及制备方法,申请号:202110113673.8(实申阶段),第一发明人.

 




北京工业大学研究生招生办公室 地址:北京市朝阳区平乐园100号 邮政编码:100124 联系电话:010-67392533