苏冬冬  



                                                                               

苏冬冬 校聘教授 博士生导师

联系电话:

通讯地址:北京市朝阳区平乐园100号

电子邮箱:chmsudd@bjut.edu.cn

教育背景                                                 

2010/08-2014/12,新加坡国立大学(National University of Singapore),化学系,博士

2007/09-2010/06,南开大学,化学学院,元素有机化学国家重点实验室,硕士

2003/09-2007/06,河北师范大学,化学与材料科学学院,学士

科研工作经历                                            

2018-至今,北京工业大学,环境与生命学部化学与生物系,校聘教授

2014-2018,新加坡科技研究局(A*STAR),新加坡生物成像研究中心,博士后

研究方向                                           

以荧光分析方法为基点,围绕生物和疾病相关物质的检测及成像面临的特异性、灵敏度及背景荧光等关键科学问题,基于新原理(荧光可控的高性能荧光染料和特异性识别反应等)构筑了系列新型荧光探针用于生物和疾病相关物质的检测,并在细胞、组织和活体成像中成功应用。

主要科研成果                                       

发表SCI论文47篇(近五年35篇),引用超过1600次,H-index 23,以第一或通讯作者在J. Am. Chem. Soc., Chem, Chem. Sci., Chem. Soc. Rev. 等发表论文23篇。2项国际专利授权,其中1项同时获美国专利授权。

  1. Chen, X.; Bian, Y.; Li, M.; Zhang, Y.; Gao, X.; Su, D.*, Activatable Off-on Near-Infrared QCy7-based Fluorogenic Probes for Bioimaging, Chem. Asian J., 2020, 15, 3983–3994

  2. Su, D.*; Chen, X.; Zhang, Y.; Gao, X.*, Activatable imaging probes for cancer-linked NAD (P) H: quinone oxidoreductase-1 (NQO1): advances and future prospects, TrAC-Trend Anal Chem, 2020, 133, 116112.

  3. Su, D.; Gao, L.; Gao, F.; Zhang, X.; Gao, X.*, Peptide and Protein Modified Metal Clusters for Cancer Diagnostics, Chem. Sci., 2020, 11, 5614.

  4. Chen, T.; Jiang, L.; Yuan, H. Q.; Zhang, Y.*; Su, D.*; Bao, G. M.*, A Flexible Paper-Based Chemosensor for Colorimetric and Ratiometric Fluorescence Detection of Toxic Oxalyl Chloride, Sens. Actuat. B, 2020, 319, 128289.

  5. Cai, P.; Su, D.; Yang, W.; He, Z.; Zhang, C.; Liu, H.; Liu, Z.; Zhang, X.; Gao, L.; Liu, Yu.; Jiang, H.; Gao, F.*; Gao, X.*, Inherently PET/CT Dual Modality Imaging Lipid Nanocapsules for Early Detection of Orthotopic Lung TumorsACS Appl. Bio Mater., 2020, 3, 611−621.

  6. Su, D.*; Cheng, D.; Lv, Y.; Ren, X.; Wu, Q.; Yuan, L.*, A unique off-on near-infrared QCy7-derived probe for selective detection and imaging of hydrogen sulfide in cells and in vivo, Spectrochim. Acta. A, 2020, 226, 117635.

  7. Liu, Y.; Ren, T-B.; Cheng, D.; Hou, J.; Su, D.*; Yuan, L.*, An ESIPT-Based Ratiometric Fluorescent Probe for Highly Sensitive and Rapid Detection of Sulfite in Living Cells, ChemistryOpen, 2019, 8, 1251–1257.

  8. Li, W.; Gong, X.; Fan, X.; Yin, S.; Su, D.*; Zhang, X.; Yuan, L.*, Recent advances in molecular fluorescent probes for organic phosphate biomolecules recognition, Chin. Chem. Lett., 2019, 30, 1775-1790.

  9. Duan, C.; Zhang, J. F.; Hu, Y., Zeng, L.*; Su, D.*; Bao, G. M.*, A distinctive near-infrared fluorescence turn-on probe for rapid, sensitive and chromogenic detection of sulfite in food, Dyes Pigments, 2019, 162, 459-465. (IF: 3.8)

  10. Su, D.; Teoh, C. L.; Park, S. J.; Kim, J. Y.; Samanta, A.; Bi, R.; Dinish, U. S.; Olivo, M.; Piantino, M.; Louis, F.; Matsusaki, M.; Kim, S. S.; Bae, M. A.; Chang, Y. T.*, Seeing Elastin: A Near-Infrared Zwitterionic Fluorescent Probe for In Vivo Elastin Imaging, Chem, 2018,4,1128-1138. (IF: 14.1)

  11. Wu, J.; Pan, J.; Ye, Z.; Zeng, L.*; Su, D.*, A smart fluorescent probe for discriminative detection of hydrazine and bisulfite from different emission channels, Sens. Actuat. B, 2018, 274, 274-284. (IF: 5.7)

  12. Ye, Z.; Xiong, C.; Pan, J.; Su, D.*; Zeng, L.*, Highly photostable, lysosome-targeted BODIPYs with green to near-infrared emission for lysosome imaging in living cells, Dyes Pigments, 2018, 155, 30-35. (IF: 3.8)

  13. Alamudi, S. H.; Su, D.; Lee, K. J.; Lee, J. Y.; Belmonte-Vázquez, J. L.; Park, H. S.; Peña-Cabrera, E.; Chang, Y. T.*, A Palette of Background-Free Tame Fluorescent Probes for Intracellular Multi-Color Labelling in Live Cells, Chem. Sci., 2018, 9, 2376-2383. (Co-first authors). (IF: 9.1)

  14. Wang, L.; Su, D.; Berry, S. N.; Lee, J. Y.; Chang, Y. T.*, A New Approach for Turn-on Fluorescence Sensing of L-DOPA, Chem. Comm., 2017, 53, 12465-12468. (Co-first authors). (IF: 6.3)

  15. Su, D.; Teoh, C. L.; Wang, L.; Liu, X.; Chang, Y. T.*, Motion-induced change in emission (MICE) for developing fluorescent probes, Chem. Soc. Rev., 2017, 46, 4833-4844. (Back inside cover article) (IF: 40.2)

  16. Su, D.; Teoh, C. L.; Gao, N.; Xu, Q. H.; Chang, Y. T.*, A Simple BODIPY-Based Viscosity Probe for Imaging of Cellular Viscosity in Live Cells. Sensors, 2016, 16, 1397. (Co-first authors) (IF: 2.5)

  17. Teoh, C. L.; Su, D.; Sahu, S.; Yun, S. W.; Drummond, E.; Prelli, F.; Lim, S.; Cho, S.; Ham, S.*; Wisniewski, T.*; Chang, Y. T.*, Chemical Fluorescent Probe for Detection of Aβ Oligomers, J. Am. Chem. Soc., 2015, 137, 13503-13509. (Co-first authors), this work was chosen as cover article and selected as JACS Spotlights, J. Am. Chem. Soc., 2015, 137, 10017-10017. (IF: 14.4) 

  18. Su, D.; Teoh, C. L.; Samanta, A.; Kang, N. Y.; Park, S. J.; Chang, Y. T.*, The Development of a Highly Photostable and Chemically Stable Zwitterionic Near-Infrared Dye for Imaging Applications, Chem. Comm., 2015, 51, 3989-3992. (IF: 6.3)

  19. Su, D.; Teoh, C. L.; Kang, N. Y.; Yu, X.; Sahu, S.; Chang, Y. T.*, Synthesis and Systematic Evaluation of Dark Resonance Energy Transfer (DRET)-based Library and Its Application in Cell Imaging, Chem. Asian J., 2015, 10, 581-585. (IF: 3.7)

  20. Su, D.; Oh, J.; Lee, S. C.; Lim, J. M.; Sahu, S.; Yu, X.; Kim, D.; and Chang, Y. T.*, Dark to light! A new strategy for large Stokes shift dyes: coupling of a dark donor with tunable high quantum yield acceptors, Chem. Sci., 2014, 5, 4812-4818. (IF: 9.1)

  21. Su, D.; Teoh, C. L.; Sahu, S.; Das, R. K.; Chang, Y. T.*, Live cells imaging using a turn-on FRET-based BODIPY probe for biothiols, Biomaterials, 2014, 35, 6078-6085. (IF: 8.8)

    在研科研项目 

    1.  国家自然科学基金青年基金项目,21708029,基于生物正交反应的活细胞内多细胞器多色同时荧光标记及成像研究,2018/01-2020/12,直接经费25万元,主持。

    2. 北京市教委科研计划科技重点项目(市教委-市基金联合资助项目),KZ202010005006,活体内自组装荧光/CT双模态增强成像与放射性治疗一体化探针设计研究,2020/01-2022/12,经费80万元,主持。

    3.北京工业大学优秀人才计划项目,2019/01-2023/12,经费100万元,主持。

                                             


北京工业大学研究生招生办公室 地址:北京市朝阳区平乐园100号 邮政编码:100124 联系电话:010-67392533