高靓  

                                                                               

高靓 (副教授,硕士生导师)

联系电话:

通讯地址:北京市朝阳区平乐园100号

电子邮箱:gaoliang@bjut.edu.cn

 

教育背景                                                 

  • 2003-2007年,山东大学获得本科学位

  • 2007-2012年,中国科学院化学研究所获得博士学位

     

科研工作经历                                            

  • 2012-2014年,中国科学院高能物理研究所,博士后

  • 2014-2015年,中国科学院高能物理研究所,助理研究员

  • 2015-2017年,中国科学院高能物理研究所,副研究员

  • 2017年-至今,北京工业大学,校聘教授

     

研究方向                                           

  • 发展生物大分子原位分析方法,实现目标蛋白的原位标记、可视化成像与精确定量检测, 以期指导重大疾病的诊断、分期及治疗的评估。

  • 筛选高效、低毒、具有选择性催化活性的金属团簇或纳米颗粒为潜在的金属类药物,为开发新颖的金属类分子靶向治疗药物提供前期基础。

 

主要科研成果                                       

第一作者及通讯作者论著

  1. An Artificial Metalloenzyme for Catalytic Cancer-Specific DNA Cleavage and Operando Imaging. Sci. Adv. 2020, 6, eabb1421.

  2. Is GSH Chelated Pt Molecule Inactive in Anti-Cancer Treatment? A Case Study of Pt6GS4. Small 2020, 16, 2002044.

  3. The Precise Diagnosis of Cancer Invasion/Metastasis via 2D Laser Ablation Mass Mapping of Metalloproteinase in Primary Cancer Tissue. ACS Nano 2018, 12, 11139.

  4. Peptide-Au Clusters Induced Tumor Cells Apoptosis via Targeting Glutathione Peroxidase-1: The Molecular Dynamics Assisted Experimental Studies. Sci. Rep. 2017, 7, 131.

  5. Peptide Protected Gold Clusters: Chemical Synthesis and Biomedical Applications. Nanoscale 2016, 8, 12095.

  6. Peptide-Conjugated Gold Nanoprobe: Intrinsic Nanozyme-Linked Immunsorbant Assay of Integrin Expression Level on Cell Membrane. ACS Nano 2015, 9, 10979.

  7. Plasmon-Mediated Generation of Reactive Oxygen Species from Near-Infrared Light Excited Gold Nanocages for Photodynamic Therapy in Vitro. ACS Nano 2014, 8, 7260.

  8. Positively Charged Graphene Oxide Nanoparticle: Precisely Label the Plasma Membrane of Live Cell and Sensitively Monitor Extracellular pH in Situ. Chem. Commun. 2014, 50, 3695.

  9. Hypocrellin-Loaded Gold Nanocages with High Two-Photon Efficiency for Photothermal/Photodynamic Cancer Therapy in Vitro. ACS Nano 2012, 6, 8030.

  10. pH- and Redox-Responsive Polysaccharide-Based Microcapsules with Autofluorescence for Biomedical Applications. Chem. Eur. J. 2012, 18, 3185.

  11. Selective Recognition of Co-assembled Thrombin Aptamer and Docetaxel on Mesoporous Silica Nanoparticles against Tumor Cell Proliferation. Chem. Eur. J. 2011, 17, 13170.

在研科研项目

  1. 国家自然科学基金面上项目,主持,2018.1-2021.12,在研

  2. 北京市教委-市自然基金联合资助项目,主持,2020.1-2022.12,在研

  3. 国家自然科学基金青年项目,主持,2016.1-2018.12,结题

                                           


北京工业大学研究生招生办公室 地址:北京市朝阳区平乐园100号 邮政编码:100124 联系电话:010-67392533